Browsing by Author "Margusino-Framiñán, Luis"
Now showing items 1-18 of 18
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Clinical experience with the integrase inhibitors Dolutegravir and Elvitegravir in HIV-infected patients: efficacy, safety and tolerance
Cid-Silva, Purificación; Llibre, Josep M.; Fernández-Bargiela, Noelia; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Pernas, Berta; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Poveda, Eva (Wiley, 2017-07-16)[Abstract] Two integrase inhibitors (INSTIs), dolutegravir (DTG) and elvitegravir/cobicistat (EVG/COBI), have joined recently the pharmacotherapy arsenal against HIV. This study evaluated the efficacy and tolerability of ... -
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Pita-Gutiérrez, Francisco; Pita-Fernández, Salvador; Cordido, Fernando (Elsevier, 2015-08-20)[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ... -
Darunavir/cobicistat maintains the effectiveness of darunavir/ritonavir in HIV-infected patients under mono or dual therapy
Mena, Álvaro; Cid-Silva, Purificación; Dueñas, Carlos; Garcinuño, María Ángeles; Lorenzo, Juan Francisco; Margusino-Framiñán, Luis; Quiñones, Marina; Grande, Carmen; Rodríguez-Osorio, Iria; Castro-Iglesias, Ángeles (Taylor & Francis, 2019-01-03)[Abstract] OBJECTIVES: Darunavir/ritonavir (DRV/r) in mono or dual therapy has proven efficacy in selected patients. The aim of this study was to evaluate the efficacy of switching from DRV/r to DRV/cobicistat (DRV/c) in ... -
Discontinuation due to neuropsychiatric adverse events with efavirenz- and dolutegravir-based antiretroviral therapy: a comparative real-life study
Fernández-Bargiela, Noelia; Rotea-Salvo, Sandra; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Mena-De-Cea, Álvaro; López-Calvo, Soledad; Vázquez-Rodríguez, Pilar; Míguez-Rey, Enrique; Cid-Silva, Purificación (BMJ, 2020-10-13)[Abstract] Objectives: Despite the high efficacy of antiretroviral treatment, no drug is free from adverse events (AEs). Efavirenz (EFV) and dolutegravir (DTG) are antiretroviral drugs for which neuropsychiatric adverse ... -
Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales
Margusino-Framiñán, Luis (2020)[Resumen] El virus de la hepatitis C (VHC) es un virus ácido ribonucleico (ARN) monocatenario identificado como el agente etiológico de la hepatitis C. El principal órgano diana del VHC es el hígado, donde puede desarrollar ... -
Effectiveness and safety of daclatasvir/sofosbuvir with or without ribavirin in genotype 3 hepatitis C virus infected patients: results in real clinical practice
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Mena, Álvaro; Rodríguez-Osorio, Iria; Pernas, Berta; Delgado, Manuel; Pértega-Díaz, Sonia; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (Sociedad Española de Quimioterapia, 2019)[Abstract] OBJECTIVE: Direct-acting antivirals have shown high efficacy in all hepatitis C virus (HCV) genotypes, but genotype 3 (G3) treatments continue to be a challenge, mainly in cirrhotic patients. The aim of this ... -
Effectiveness and Safety of Direct‐Acting Antivirals in Hepatitis C Infected Patients With Mental Disorders: Results in Real Clinical Practice
Bobadilla-Pérez, Eva; Cid-Silva, Purificación; Rodríguez‐Sotelo, Alejandro; Yáñez‐Rubal, Juan C.; Mena, Álvaro; Suárez-López, Francisco; Prieto‐Pérez, Andrea; Giménez‐Arufe, Víctor; Delgado, Manuel; Sanclaudio‐Luhia, Ana I.; Martín‐Herranz, Isabel; Castro-Iglesias, Ángeles; Margusino-Framiñán, Luis (Willey Online Library, 2020-03-17)[Abstract] The aim of this study is to analyze the effectiveness and safety of direct‐acting antivirals (DAAs) in psychiatric patients with chronic hepatitis C (CHC). Secondary objectives included adherence and drug‐drug ... -
Effectiveness and Safety of Sofosbuvir/Velpatasvir ± Ribavirin vs Glecaprevir/Pibrentasvir in Genotype 3 Hepatitis C Virus Infected Patients
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Rotea-Salvo, Sandra; Mena, Álvaro; Suárez-López, Francisco; Vázquez-Rodríguez, Pilar; Delgado, Manuel; Sanclaudio-Luhia, Ana I.; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (BMJ Publishing Group, 2020-02-07)[Abstract] Objectives. Sofosbuvir/velpatasvir±ribavirin (SOF/VEL±RBV) and glecaprevir/pibrentasvir (GLE/PIB) are the drug combinations of choice for treating individuals with genotype 3 hepatitis C virus (G3-HCV) infection. ... -
Influence of drug–drug interactions on effectiveness and safety of direct-acting antivirals against hepatitis C virus
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Giménez-Arufe, Víctor; Mondelo-García, Cristina; Fernández-Oliveira, Carla; Mena, Álvaro; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (BMJ, 2019-06-13)[Abstract] Objectives Direct-acting antivirals are the recommended treatment for hepatitis C-infected patients. Drug–drug interactions with concomitant treatments can cause lack of effectiveness and/or safety. The objective ... -
Late HIV diagnosis but earlier antiretroviral treatment initiation in northwest Spain: impact of current treatment guidelines
Cid-Silva, Purificación; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Pernas, Berta; Mena, Álvaro; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Poveda, Eva (Sage, 2019-01-10)[Abstract] Background: Current HIV treatment guidelines recommend antiretroviral treatment (ART) initiation for all HIV-infected individuals regardless of CD4 count. This study evaluates the immunological and virological ... -
Liver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antivirals
Rodríguez-Osorio, Iria; Mena, Álvaro; Meijide, Héctor; Morano, Luis; Delgado, Manuel; Cid-Silva, Purificación; Margusino-Framiñán, Luis; Pedreira, José D.; Castro-Iglesias, Ángeles (Plos ONE, 2019-06-03)[Abstract] BACKGROUND: Direct-acting antivirals (DAAs) are effective in patients aged ≥65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular ... -
Long-term clinical experience with darunavir (2007–2015) in a large cohort of HIV-infected patients in Spain authors
Pernas, Berta; Grandal, Marta; Tabernilla, Andrés; Cid-Silva, Purificación; Pértega-Díaz, Sonia; Castro-Iglesias, Ángeles; Mena, Álvaro; Margusino-Framiñán, Luis; Pedreira, José D.; Poveda, Eva (Wiley, 2016-06-06)[Abstract] The clinical experience with the protease inhibitor darunavir/ritonavir (DRV/r) was retrospectively evaluated in a cohort of 173 HIV+ patients who initiated antiretroviral treatment including DRV/r (period ... -
Outpatients' opinion and experience regarding telepharmacy during the COVID-19 pandemic: the Enopex Project
Margusino-Framiñán, Luis; Fernández-Llamazares, Cecilia M.; Negro-Vera, Eva; Tortajada.Goitia, Begoña; Lizeaga, Garbiñe; Mercadal-Orfila, Gabriel; Almeida-González, Carmen; Morillo-Verdugo, Ramón (Dove Press, 2021-12-31)[Abstract] Background: Telepharmacy, as a remote pharmaceutical care procedure, is being used worldwide during the COVID-19 pandemic, with the aim of preserving the health of patients and professionals. Its future development ... -
Paritaprevir-ritonavir, ombitasvir and dasabuvir plus ribavirin to treat hepatitis C genotype 1 infection after liver transplantation: a single-center experience
Otero, Alejandra; Vázquez, María Ángeles; Suárez, Francisco; Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Gómez, Manuel (Open Access Text, 2017-05-23)[Abstract] Hepatitis C virus (HCV) infection is a disease with a significant worldwide impact. In Europe and the United States, chronic hepatitis C is the most common cause of chronic hepatic disease and the main indication ... -
Real life experience with direct-acting antivirals agents against hepatitis C infection in elderly patients
Rodríguez-Osorio, Iria; Cid-Silva, Purificación; Morano, Luis; Castro-Iglesias, Ángeles; Suárez, Marta; Delgado, Manuel; Margusino-Framiñán, Luis; Meijide, Héctor; Pernas, Berta; Tabernilla, Andrés; Pedreira, José D.; Mena, Álvaro; Poveda, Eva (Elsevier, 2017-01-18)[Abstract] Background. New direct-acting antivirals agents (DAAs) are very safe and well tolerated. Objectives. The purpose of this study is to analyse the efficacy and safety of DAAs in elderly patients, who have ... -
Renal profile of patients treated with elvitegravir/ cobicistat/emtricitabine/tenofovir alafenamide fumarate and dolutegravir/abacavir/lamivudine: 120-week results from a real-world cohort
Rotea-Salvo, Sandra; Martínez-Pradeda, Alejandro; Fernández-Oliveira, Carla; Giménez-Arufe, Víctor; Balboa-Barreiro, Vanesa; Margusino-Framiñán, Luis; Mena-De-Cea, Álvaro; Vázquez-Rodríguez, Pilar; Castro-Iglesias, Ángeles; López-Calvo, Soledad; Martín-Herranz, Isabel; Míguez-Rey, Enrique; Cid-Silva, Purificación (BMJ, 2021-10-14)[Abstract] Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) and dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) are currently available for HIV patients. Objectives: This study evaluated ... -
Teleconsultation for the pharmaceutical care of HIV outpatients in receipt of home antiretrovirals delivery: clinical, economic, and patient-perceived quality analysis
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Castro-Iglesias, Ángeles; Mena, Álvaro; Rodríguez-Osorio, Iria; Pernas Souto, Berta; Vázquez-Rodríguez, Pilar; López-Calvo, Soledad; Martín-Herranz, Isabel (Mary Ann Liebert, 2018-07-19)[Abstract] Background/Introduction: Pharmacist teleconsultations, combined with home drug delivery or mail-order pharmacy (MOP), can help hospital outpatients with difficulties accessing treatment. The objectives of this ... -
Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV‐infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine
Cid-Silva, Purificación; Fernández-Bargiela, Noelia; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Mena, Álvaro; López-Calvo, Soledad; Vázquez-Rodríguez, Pilar; Martín-Herranz, Isabel; Míguez-Rey, Martín; Poveda, Eva; Castro-Iglesias, Ángeles (Wiley, 2018-11-02)[Abstract] Two elvitegravir/cobicistat‐based therapies combined with emtricitabine/tenofovir disoproxil fumarate (EVG/c/FTC/TDF) or emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) are currently available for ...
