Browsing by Author "Margusino-Framiñán, Luis"
Now showing items 1-20 of 24
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Analysing early diagnosis strategies for HIV infection: a retrospective study of missed diagnostic opportunities
Giménez-Arufe, Víctor; Rotea-Salvo, Sandra; Martínez-Pradera, Alejandro; Mena-de-Cea, Álvaro; Margusino-Framiñán, Luis; Suanzes-Hernández, Jorge; Martín-Herranz, Isabel; Cid-Silva, Purificación (MDPI, 2024-01-31)[Abstract] Early diagnosis of a Human Immunodeficiency Virus (HIV)-infected person represents a cornerstone of HIV prevention, treatment, and care. Numerous publications have developed recommendations where HIV serology ... -
Clinical experience with the integrase inhibitors Dolutegravir and Elvitegravir in HIV-infected patients: efficacy, safety and tolerance
Cid-Silva, Purificación; Llibre, Josep M.; Fernández-Bargiela, Noelia; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Pernas, Berta; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Poveda, Eva (Wiley, 2017-07-16)[Abstract] Two integrase inhibitors (INSTIs), dolutegravir (DTG) and elvitegravir/cobicistat (EVG/COBI), have joined recently the pharmacotherapy arsenal against HIV. This study evaluated the efficacy and tolerability of ... -
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Pita-Gutiérrez, Francisco; Pita-Fernández, Salvador; Cordido, Fernando (Elsevier, 2015-08-20)[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ... -
Dalbavancin as consolidation therapy for infective endocarditis in patients with comorbidity: a real world experience
Brandariz-Núñez, David; Luances-Rodríguez, Andrea; Feijoo-Vilanova, Pablo; Gutiérrez-Urbón, José María; Ramuso Cela, Luis; Martín-Herranz, Isabel; Margusino-Framiñán, Luis (Sociedad Española de Quimioterapia, 2024-06-17)[Resumen] Objective: Infective endocarditis (IE) is a potentially life-threatening infection, the incidence of which has in creased in recent decades, particularly among elderly patients with comorbidity. The primary ... -
Darunavir/cobicistat maintains the effectiveness of darunavir/ritonavir in HIV-infected patients under mono or dual therapy
Mena, Álvaro; Cid-Silva, Purificación; Dueñas, Carlos; Garcinuño, María Ángeles; Lorenzo, Juan Francisco; Margusino-Framiñán, Luis; Quiñones, Marina; Grande, Carmen; Rodríguez-Osorio, Iria; Castro-Iglesias, Ángeles (Taylor & Francis, 2019-01-03)[Abstract] OBJECTIVES: Darunavir/ritonavir (DRV/r) in mono or dual therapy has proven efficacy in selected patients. The aim of this study was to evaluate the efficacy of switching from DRV/r to DRV/cobicistat (DRV/c) in ... -
Development of the @Antidotos_bot chatbot tool for poisoning management
García-Queiruga, Marta; Fernández Oliveira, Carla; Mauríz-Montero, María José; Porta-Sánchez, Ángeles; Margusino-Framiñán, Luis; Martín-Herranz, Isabel (Elsevier, 2021)[Abstract] Objective: To describe the development of the Antidotos_bot chatbot tool, which is used to facilitate the search for information in the Antidote Administration Guide and to perform useful calculations in the ... -
Discontinuation due to neuropsychiatric adverse events with efavirenz- and dolutegravir-based antiretroviral therapy: a comparative real-life study
Fernández-Bargiela, Noelia; Rotea-Salvo, Sandra; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Mena-De-Cea, Álvaro; López-Calvo, Soledad; Vázquez-Rodríguez, Pilar; Míguez-Rey, Enrique; Cid-Silva, Purificación (BMJ, 2020-10-13)[Abstract] Objectives: Despite the high efficacy of antiretroviral treatment, no drug is free from adverse events (AEs). Efavirenz (EFV) and dolutegravir (DTG) are antiretroviral drugs for which neuropsychiatric adverse ... -
Efectividad y seguridad de los antivirales de acción directa frente al virus de la hepatitis C: foco en subpoblaciones especiales
Margusino-Framiñán, Luis (2020)[Resumen] El virus de la hepatitis C (VHC) es un virus ácido ribonucleico (ARN) monocatenario identificado como el agente etiológico de la hepatitis C. El principal órgano diana del VHC es el hígado, donde puede desarrollar ... -
Effectiveness and safety of daclatasvir/sofosbuvir with or without ribavirin in genotype 3 hepatitis C virus infected patients: results in real clinical practice
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Mena, Álvaro; Rodríguez-Osorio, Iria; Pernas, Berta; Delgado, Manuel; Pértega-Díaz, Sonia; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (Sociedad Española de Quimioterapia, 2019)[Abstract] OBJECTIVE: Direct-acting antivirals have shown high efficacy in all hepatitis C virus (HCV) genotypes, but genotype 3 (G3) treatments continue to be a challenge, mainly in cirrhotic patients. The aim of this ... -
Effectiveness and safety of direct‐acting antivirals in hepatitis C infected patients with mental disorders: results in real clinical practice
Bobadilla-Pérez, Eva; Cid-Silva, Purificación; Rodríguez‐Sotelo, Alejandro; Yáñez‐Rubal, Juan C.; Mena, Álvaro; Suárez-López, Francisco; Prieto‐Pérez, Andrea; Giménez‐Arufe, Víctor; Delgado, Manuel; Sanclaudio‐Luhia, Ana I.; Martín‐Herranz, Isabel; Castro-Iglesias, Ángeles; Margusino-Framiñán, Luis (Willey Online Library, 2020-03-17)[Abstract] The aim of this study is to analyze the effectiveness and safety of direct‐acting antivirals (DAAs) in psychiatric patients with chronic hepatitis C (CHC). Secondary objectives included adherence and drug‐drug ... -
Effectiveness and safety of sofosbuvir/velpatasvir ± ribavirin vs glecaprevir/pibrentasvir in genotype 3 hepatitis C virus infected patients
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Rotea-Salvo, Sandra; Mena, Álvaro; Suárez-López, Francisco; Vázquez-Rodríguez, Pilar; Delgado, Manuel; Sanclaudio-Luhia, Ana I.; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (BMJ Publishing Group, 2020-02-07)[Abstract] Objectives. Sofosbuvir/velpatasvir±ribavirin (SOF/VEL±RBV) and glecaprevir/pibrentasvir (GLE/PIB) are the drug combinations of choice for treating individuals with genotype 3 hepatitis C virus (G3-HCV) infection. ... -
Influence of drug–drug interactions on effectiveness and safety of direct-acting antivirals against hepatitis C virus
Margusino-Framiñán, Luis; Cid-Silva, Purificación; Giménez-Arufe, Víctor; Mondelo-García, Cristina; Fernández-Oliveira, Carla; Mena, Álvaro; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles (BMJ, 2019-06-13)[Abstract] Objectives Direct-acting antivirals are the recommended treatment for hepatitis C-infected patients. Drug–drug interactions with concomitant treatments can cause lack of effectiveness and/or safety. The objective ... -
Late HIV diagnosis but earlier antiretroviral treatment initiation in northwest Spain: impact of current treatment guidelines
Cid-Silva, Purificación; Margusino-Framiñán, Luis; Balboa-Barreiro, Vanesa; Pernas, Berta; Mena, Álvaro; Martín-Herranz, Isabel; Castro-Iglesias, Ángeles; Poveda, Eva (Sage, 2019-01-10)[Abstract] Background: Current HIV treatment guidelines recommend antiretroviral treatment (ART) initiation for all HIV-infected individuals regardless of CD4 count. This study evaluates the immunological and virological ... -
Lipid profile changes associated with antiretroviral therapies in a real-world cohort
Rotea-Salvo, Sandra; Giménez-Arufe, Víctor; Martínez-Pradeda, Alejandro; Fernández Oliveira, Carla; Mena-de-Cea, Álvaro; Margusino-Framiñán, Luis; Martín-Herranz, Isabel; Cid-Silva, Purificación (Elsevier, 2023-06-20)[Abstract] Objective: To compare lipid profile changes and cardiovascular events among HIV naïve and experienced patients from a real-world cohort treated with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide ... -
Liver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antivirals
Rodríguez-Osorio, Iria; Mena, Álvaro; Meijide, Héctor; Morano, Luis; Delgado, Manuel; Cid-Silva, Purificación; Margusino-Framiñán, Luis; Pedreira, José D.; Castro-Iglesias, Ángeles (Plos ONE, 2019-06-03)[Abstract] BACKGROUND: Direct-acting antivirals (DAAs) are effective in patients aged ≥65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular ... -
Long-term clinical experience with darunavir (2007–2015) in a large cohort of HIV-infected patients in Spain authors
Pernas, Berta; Grandal, Marta; Tabernilla, Andrés; Cid-Silva, Purificación; Pértega-Díaz, Sonia; Castro-Iglesias, Ángeles; Mena, Álvaro; Margusino-Framiñán, Luis; Pedreira, José D.; Poveda, Eva (Wiley, 2016-06-06)[Abstract] The clinical experience with the protease inhibitor darunavir/ritonavir (DRV/r) was retrospectively evaluated in a cohort of 173 HIV+ patients who initiated antiretroviral treatment including DRV/r (period ... -
Medication reconciliation for patients after their discharge from intensive care unit to the hospital ward
Martínez-Pradeda, Alejandro; Albiñana Pérez, María Sandra; Fernández Oliveira, Carla; Díaz Lamas, Ana; Rey Abalo, Marta; Margusino-Framiñán, Luis; Cid-Silva, Purificación; Martín-Herranz, Isabel (Elsevier, 2023-04-18)[Abstract] Objectives: The aim of this study was to determine whether the transition of care from the intensive care unit to the ward would pose a high risk for reconciliation errors. The primary outcome of this study ... -
Outpatients' opinion and experience regarding telepharmacy during the COVID-19 pandemic: the Enopex Project
Margusino-Framiñán, Luis; Fernández-Llamazares, Cecilia M.; Negro-Vera, Eva; Tortajada.Goitia, Begoña; Lizeaga, Garbiñe; Mercadal-Orfila, Gabriel; Almeida-González, Carmen; Morillo-Verdugo, Ramón (Dove Press, 2021-12-31)[Abstract] Background: Telepharmacy, as a remote pharmaceutical care procedure, is being used worldwide during the COVID-19 pandemic, with the aim of preserving the health of patients and professionals. Its future development ... -
Paritaprevir-ritonavir, ombitasvir and dasabuvir plus ribavirin to treat hepatitis C genotype 1 infection after liver transplantation: a single-center experience
Otero, Alejandra; Vázquez, María Ángeles; Suárez, Francisco; Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Gómez, Manuel (Open Access Text, 2017-05-23)[Abstract] Hepatitis C virus (HCV) infection is a disease with a significant worldwide impact. In Europe and the United States, chronic hepatitis C is the most common cause of chronic hepatic disease and the main indication ... -
Prevalence of adverse drug reactions associated with emergency department visits and risk factors for hospitalization
Brandariz-Núñez, David; Ferreiro-Gómez, Manuel; Suanzes-Hernández, Jorge; Margusino-Framiñán, Luis; De la Cámara-Gómez, María; Fandiño-Orgueira, José Manuel; Martín-Herranz, Isabel (Elsevier, 2022-12-28)[Abstract] Objective: Adverse drug reactions increase morbidity and mortality, prolong hospital stay and increase healthcare costs. The primary objective of this study was to determine the prevalence of emergency ...