Browsing by Author "Lizasoain, Ignacio"

Now showing items 1-6 of 6

    • Cav-1 protein levels in serum and infarcted brain correlate with hemorrhagic volume in a mouse model of thromboembolic stroke, independently of rt-PA administration 

      Gubern-Mérida, Carme; Comajoan, Pau; Huguet, Gemma; García-Yebenes, Isaac; Lizasoain, Ignacio; Moro, María Ángeles; Puig-Parnau, Irene; Sánchez, Juan Manuel; Serena, Joaquín; Kádár, Elisabet; Castellanos, María del Mar (Springer Nature, 2022-01-05)
      [Abstract] Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for acute ischemic stroke. However, its administration is still limited due to the associated ...

    • Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke 

      Blanco, Miguel; Moro, María Ángeles; Dávalos, Antonio; Leira, Rogelio; Castellanos, María del Mar; Serena, Joaquín; Vivancos, José; Rodríguez-Yáñez, Manuel; Lizasoain, Ignacio; Castillo, José (American Heart Association, 2005-05-05)
      [Abstract] Background and purpose: The 15-deoxyDelta prostaglandin J2 (15-dPGJ2) is an anti-inflammatory prostaglandin that has been proposed to be the endogenous ligand of peroxisome proliferator-activated receptor-gamma ...

    • MiRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis 

      Gubern-Mérida, Carme; Camós, Susanna; Ballesteros, Iván; Rodríguez, Rocío; Romera, Víctor G.; Cañadas, Roberto; Lizasoain, Ignacio; Moro, María Ángeles; Serena, Joaquín; Mallolas, Judith; Castellanos, María del Mar (FEBS Press, 2013-10-01)
      [Abstract] Despite the large number of molecules reported as being over-expressed after ischaemia, little is known regarding their regulation. miRNAs are potent post-transcriptional regulators of gene expression, and reports ...

    • Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke 

      Castellanos, María del Mar; Leira, Rogelio; Serena, Joaquín; Pumar, José Manuel; Lizasoain, Ignacio; Castillo, José; Dávalos, Antoni (American Heart Association, 2002-12-05)
      [Abstract] Background and purpose: Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship ...

    • Safety and efficacy of ApTOLL in patients with ischemic stroke undergoing endovascular treatment: a phase 1/2 randomized clinical trial 

      Hernández-Jiménez, Macarena; Abad-Santos, Francisco; Cotgreave, Ian; Gallego, Jaime; Jilma, Bernd; Flores, Alan; Jovin, Tudor G.; Vivancos, José; Hernández-Pérez, María; Molina, Carlos A.; Montaner, Joan; Casariego, Joaquín; Dalsgaard, Mads; Liebeskind, David S.; Cobo, Erik; Castellanos, María del Mar; Cardona Portela, Pere; Masjuan, Jaime; Moniche, Francisco; Tembl, José Ignacio; Terceño Izaga, Mikel; Arenillas, Juan; Calleja, Patricia; Olivot, Jean Marc; Calviere, Lionel; Henon, Hilde; Mazighi, Mikael; Piñeiro, David; Pugliese, Marco; González, Víctor M.; Moro, María Ángeles; García-Tornel, Álvaro; Lizasoain, Ignacio; Ribo, Marc (American Medical Association, 2023-06-20)
      [Abstract] Importance: ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. Objective: To assess the safety and efficacy of ApTOLL in combination with ...

    • Statin treatment withdrawal in ischemic stroke: a controlled randomized study 

      Blanco, Miguel; Nombela, Florentino; Castellanos, María del Mar; Rodríguez-Yáñez, Manuel; García-Gil, María del Mar; Leira, Rogelio; Lizasoain, Ignacio; Serena, Joaquín; Vivancos, José; Moro, María Ángeles; Dávalos, Antoni; Castillo, José (American Academy of Neurology, 2007-08-28)
      [Abstract] Background: Pretreatment with statins has been shown to reduce brain injury in cerebral ischemia. In this controlled randomized study, we investigated the influence of statin pretreatment and its withdrawal on ...