Browsing by Author "Laffon, Blanca"
Now showing items 1-20 of 52
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Applicability of EU(7)-PIM criteria in cross-national studies in European countries
Fialová, Daniela; Brkić, Jovana; Laffon, Blanca; Reissigová, Jindra; Grešáková, Silvia; Dogan, Soner; Doro, Peter; Tasić, Ljiljana; Marinković, Valentina; Valdiglesias, Vanessa; Costa, Solange; Kostřiba, Jan (2019)[Abstract] Background: The European Union (EU)(7)-PIM (potentially inappropriate medication) list presents the most comprehensive and up-to-date tool for evaluation of PIM prescribing in Europe; however, several ... -
Are immune activation and inflammaging involved in the physiopathology of frailty in older adults?
Laffon, Blanca; Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Gostner, Johanna; Fuchs, Dietmar; Pásaro, Eduardo; Valdiglesias, Vanessa (De Gruyter, 2019-06-15) -
Assessing the in Vitro Toxicity of Airborne (Nano)Particles to the Human Respiratory System: From Basic to Advanced Models [Review]
Bessa, Maria João; Brandão, Fátima; Rosário, Fernanda; Moreira, Luciana Maria Vaz; Reis, Ana Teresa; Valdiglesias, Vanessa; Laffon, Blanca; Fraga, S.; Teixeira, Joao (Taylor & Francis, 2023-01-24)[Abstract] Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between ... -
Assessment of Okadaic Acid Effects on Cytotoxicity, DNA Damage and DNA Repair in Human Cells
Valdiglesias, Vanessa; Méndez, Josefina; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Laffon, Blanca (Elsevier, 2010-05-26)[Abstract] Okadaic acid (OA) is a phycotoxin produced by several types of dinoflagellates causing diarrheic shellfish poisoning (DSP) in humans. Symptoms induced by DSP toxins are mainly gastrointestinal, but the intoxication ... -
Association Between Cognitive Reserve Proxies and Frailty Phenotype: Data from UK Biobank
Lorenzo-López, Laura; Cibeira, Nuria; Hemadeh, Ali; López-López, Rocío; Lema-Arranz, Carlota; Maseda, Ana; Fernández-Bertólez, Natalia; Costa, Solange; Pásaro, Eduardo; Valdiglesias, Vanessa; Millán-Calenti, José Carlos; Laffon, Blanca (Springer Nature, 2024-10-14)[Abstract] A potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. ... -
Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts
Giacconi, Robertina; Laffon, Blanca; Costa, Solange; Teixeira-Gomes, Armanda; Maggi, Fabrizio; Macera, Lisa; Spezia, Pietro Giogio; Piacenza, Francesco; Bürkle, Alexander; Moreno-Villanueva, María; Bonassi, Stefano; Valdiglesias, Vanessa; Teixeira, Joao Paulo; Dollé, Martijn E.T.; Rietman, M. Liset; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S.; Franchesci, Claudio; Capri, Miriam; Weinberger, Birgit; Sikora, Ewa; Stuetz, Wolfgang; Toussaint, Olivier; Debacq-Chainiaux, Florence; Hervonen, Antti; Hurme, Mikko; Slagboom, P. Eline; Schön, Christiane; Bernhardt, Jürgen; Breusing, Nicolle; Pásaro, Eduardo; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Provinciali, Mauro; Malavolta, Marco (Karger, 2023-01-10)[Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, ... -
Comparative Study of Human Neuronal and Glial Cell Sensitivity for in Vitro Neurogenotoxicity Testing
Laffon, Blanca; Fernández-Bertólez, Natalia; Costa, C.; Pásaro, Eduardo; Valdiglesias, Vanessa (Elsevier, 2017-02-03)[Abstract] Cell cultures from neuronal and glial origin have proven to be powerful tools for elucidating cellular and molecular mechanisms of nervous system development and physiology, and as neurotoxicity models to evaluate ... -
Comparative Study on Effects of Two Different Types of Titanium Dioxide Nanoparticles on Human Neuronal Cells
Valdiglesias, Vanessa; Costa, C.; Sharma, Vyom; Kiliç, Gözde; Pásaro, Eduardo; Teixeira, João Paulo; Dhawan, Alok; Laffon, Blanca (Elsevier, 2013-04-15)[Abstract] Titanium dioxide (TiO2) are among most frequently used nanoparticles (NPs). They are present in a variety of consumer products, including food industry in which they are employed as an additive. The potential ... -
Cytogenetic Effects Induced by Prestige Oil on Human Populations: The Role of Polymorphisms in Genes Involved in Metabolism and DNA Repair
Pérez-Cadahía, Beatriz; Laffon, Blanca; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina (Elsevier, 2008-04-18)[Abstract] The spill from the oil tanker Prestige (NW Spain, November 2002) was perhaps the biggest ecological disaster that happened worldwide in the last decades. As a consequence of this catastrophe a general concern ... -
De la Diplomatura al Grado en Logopedia: influencia sobre las tasas de éxito y rendimiento en una asignatura obligatoria
Laffon, Blanca; Valdiglesias, Vanessa (Universidade da Coruña, Cufie, 2018)[Resumen] El proceso de convergencia hacia el Espacio Europeo de Educación Superior (EEES) es hoy día un hecho, y lleva en funcionamiento tiempo suficiente para permitir la realización de comparaciones. Como consecuencia ... -
DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death
Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Neri, Monica; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine; Teixeira, João; Bruzzone, Marco; Da Silva, Juliana; Benedetti, Danieli; Cavallo, Delia; Ursini, Cinzia Lucia; Giovannelli, Lisa; Moretti, Silvia; Riso, Patrizia; Del Bo’, Cristian; Russo, Patrizia; Dobrzyńska, Malgorzata; Goroshinskaya, Irina A.; Surikova, Ekaterina; Staruchova, Marta; Barančoková, Magdaléna; Volkovova, Katarina; Kažimírová, Alena; Smolkova, Bozena; Laffon, Blanca; Valdiglesias, Vanessa; Pastor, Susana; Marcos, Ricard; Hernández, Alba; Gajski, Goran; Spremo-Potparević, Biljana; Živković, Lada; Boutet-Robinet, Elisa; Perdry, Hervé; Lebailly, Pierre; Pérez, Carlos L.; Başaran, Nurşen; Nemeth, Zsuzsanna; Sáfár, Anna; Dusinska, Maria; Collins, Andrew (2021)[Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, ... -
Early Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis
Prego-Faraldo, María Verónica; Valdiglesias, Vanessa; Laffon, Blanca; Méndez, Josefina; Eirín-López, J.M. (Multidisciplinary Digital Publishing Institute, 2016)Okadaic acid (OA) and dinophysistoxins (DTXs) are the main toxins responsible for diarrhetic shellfish poisoning (DSP) intoxications during harmful algal blooms (HABs). Although the genotoxic and cytotoxic responses to OA ... -
Effects of degree of urbanization and lifetime longest-held occupation on cognitive impairment prevalence in an older spanish population
Lorenzo-López, Laura; Millán-Calenti, José Carlos; López-López, Rocío; Diego-Díez, Clara; Laffon, Blanca; Pásaro, Eduardo; Valdiglesias, Vanessa; Maseda, Ana (Frontiers, 2017-02-13)[Abstract] Our aim was to estimate the prevalence of cognitive impairment in rural and urban elderly populations and to examine the relationship between lifetime occupation and general cognitive performance. A cross-sectional ... -
Effects of Iron Oxide Nanoparticles: Cytotoxicity, Genotoxicity, Developmental Toxicity, and Neurotoxicity
Valdiglesias, Vanessa; Kiliç, Gözde; Costa, C.; Fernández-Bertólez, Natalia; Pásaro, Eduardo; Teixeira, João; Laffon, Blanca (Wiley, 2014-08-22)[Abstract] Iron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, ... -
Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos
Valdiglesias, Vanessa; Alba-González, Anabel; Fernández-Bertólez, Natalia; Touzani, Assia; Ramos-Pan, Lucía; Reis, Ana Teresa; Moreda-Piñeiro, Jorge; Yáñez, Julián; Laffon, Blanca; Folgueira, Mónica (MDPI, 2023-08-01)[Abstract] Zinc oxide nanoparticles (ZnO NPs) are among the most widely used nanomaterials. They have multiple applications in cosmetics, textiles, paints, electronics and, recently, also in biomedicine. This extensive use ... -
Endocrine and Immunological Parameters in Individuals Involved in Prestige Spill Cleanup Tasks Seven Years After the Exposure
Laffon, Blanca; Aguilera, Francisco; Ríos-Vázquez, Julia; García Lestón, Julia; Fuchs, Dietmar; Valdiglesias, Vanessa; Pásaro, Eduardo (Elsevier, 2013-06-20)[Abstract] In November 2002 the oil tanker Prestige spilled 63,000tonnes of heavy oil off the northwest coast of Spain, impacting more than 1000km of coastline. A general concern led to a huge mobilization of human and ... -
Evaluation of Okadaic Acid-Induced Genotoxicity in Human Cells Using the Micronucleus Test and γH2AX Analysis
Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Taylor and Francis, 2011-06-27)[Abstract] Marine algal blooms have become a public health concern due to increasing frequency in the environment and severity of exposure consequences. Human intoxications produced by phycotoxins occur globally through ... -
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
Teixeira Gomes, Armanda; Laffon, Blanca; Valdiglesias, Vanessa; Gostner, Johanna; Felder, Thomas; Costa, C.; Madureira, Joana; Fuchs, Dietmar; Teixeira, João; Costa, Solange (2021)[Abstract] Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with ... -
Exploring genetic outcomes as frailty biomakers
Valdiglesias, Vanessa; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca (Oxford, 2018-04-19)[Abstract] Frailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective ... -
Frailty in older adults is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations
Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Gostner, Johanna; Fuchs, Dietmar; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Frontiers, 2018-05-16)[Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related ...