Browsing by Author "Jiménez, Carlos"
Now showing items 1-20 of 35
-
Absolute Configuration by Vibrational Circular Dichroism of Anti-inflammatory Macrolide Briarane Diterpenoids From the Gorgonian Briareum Asbestinum
Pech-Puch, Dawrin; Joseph-Nathan, Pedro; Burgueño-Tapia, Eleuterio; González-Salas, Carlos; Martínez Matamoros, Diana; Pereira, David; Pereira, Renato; Jiménez, Carlos; Rodríguez, Jaime (Springer Nature, 2021-01-12)[Abstract] The four new briarane diterpenoids 2-butyryloxybriarane B-3 (2), 9-acetylbriarenolide S (3), briarenolide W (4), and 12-isobriarenolide P (5), along with briarane B-3 (1) and the five known diterpenes 6–10 were ... -
Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation
Gaudêncio, Susana P.; Bayram, Engin; Lukić Bilela, Lada; Cueto, Mercedes; Díaz-Marrero, Ana R.; Haznedaroglu, Berat Zeki; Jiménez, Carlos; Mandalakis, Manolis; Pereira, Florbela; Reyes, Fernando; Tasdemir, Deniz (MDPI, 2023-05-19)[Abstract] Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles ... -
AHL-lactonase Expression in Three Marine Emerging Pathogenic Vibrio spp. Reduces Virulence and Mortality in Brine Shrimp (Artemia salina) and Manila Clam (Venerupis philippinarum)
Torres, Marta; Reina, José Carlos; Fuentes-Monteverde, Juan Carlos; Fernández, Gerardo; Rodríguez, Jaime; Jiménez, Carlos; Llamas, Inmaculada (PLOS, 2018-04-17)[Abstract] Bacterial infectious diseases produced by Vibrio are the main cause of economic losses in aquaculture. During recent years it has been shown that the expression of virulence genes in some Vibrio species is ... -
Anti-Inflammatory Effects of 5α,8α-Epidioxycholest-6-en-3β-ol, a Steroidal Endoperoxide Isolated from Aplysia depilans, Based on Bioguided Fractionation and NMR Analysis
Pereira, Renato; Pereira, David; Jiménez, Carlos; Rodríguez, Jaime; Nieto, Rosa M.; Videira, Romeu; Silva, Olga; Andrade, Paula B.; Valentão, Patrícia (MDPI, 2019-06-03)[Abstract:] Sea hares of "Aplysia" genus are recognized as a source of a diverse range of metabolites. 5α,8α-Endoperoxides belong to a group of oxidized sterols commonly found in marine organisms and display several ... -
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.
Pech-Puch, Dawrin; Grilo, Diana; Calva Pérez, Susana Eunice; Pedras, Andreia; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Díaz-Gamboa, Raúl E.; Forero, Abel M.; Rodríguez, Jaime; Lenis Rojas, Óscar; Jiménez, Carlos; Pimentel, Catarina (MDPI, 2023-01-06)[Abstract] Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase ... -
Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula
Pech-Puch, Dawrin; Forero, Abel M.; Fuentes-Monteverde, Juan Carlos; Lasarte-Monterrubio, Cristina; Martínez Guitián, Marta; González-Salas, Carlos; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Beceiro, Alejandro; Griesinger, Christian; Rodríguez, Jaime; Jiménez, Carlos (MDPI, 2022-04-28)[Abstract] Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and ... -
Antiviral and Antiproliferative Potential of Marine Organisms from the Yucatan Peninsula, Mexico
Pech-Puch, Dawrin; Berastegui-Cabrera, Judith; Pérez Povedano, Mar Anabel; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Cautain, Bastien; Reyes, Fernando; Pachón, Jerónimo; Gómez, Patricia; Rodríguez, Jaime; Jiménez, Carlos; Sánchez-Céspedes, Javier (Frontiers, 2020-08-20)[Abstract] Viral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human ... -
Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K
Urda, Carlos; Fernández, Rogelio; Rodríguez, Jaime; Pérez, Marta; Jiménez, Carlos; Cuevas, Carmen (Multidisciplinary Dixital Publishing Institute, 2017-07-01)[Abstract] Two novel oxazole-thiazole containing cyclic hexapeptides, bistratamides M (1) and N (2) have been isolated from the marine ascidian Lissoclinum bistratum (L. bistratum) collected in Raja Ampat (Papua Bar, ... -
Connection of Isolated Stereoclusters by Combining 13C-RCSA, RDC, and J-Based Configurational Analyses and Structural Revision of a Tetraprenyltoluquinol Chromane Meroterpenoid from Sargassum muticum
Fuentes-Monteverde, Juan Carlos; Nath, Nilamoni; Forero, Abel M.; Balboa, Elena M.; Navarro-Vázquez, Armando; Griesinger, Christian; Jiménez, Carlos; Rodríguez, Jaime (MDPI, 2022)[Abstract] The seaweed Sargassum muticum, collected on the southern coast of Galicia, yielded a tetraprenyltoluquinol chromane meroditerpene compound known as 1b, whose structure is revised. The relative configuration of ... -
Cytotoxic furanoditerpenes from the sponge Spongia tubulifera collected in the Mexican Caribbean
Pech-Puch, Dawrin; Rodríguez, Jaime; Cautain, Bastien; Sandoval-Castro, Carlos Alfredo; Jiménez, Carlos (MDPI, 2019-07-16)[Abstract] Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3, ... -
Datura stramonium Flowers as a Potential Natural Resource of Bioactive Molecules: Identification of Anti-Inflammatory Agents and Molecular Docking Analysis
Damergi, Bilel; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Tabbene, Olfa (MDPI, 2023-07-04)[Abstract] The present study investigated the antioxidant, antibacterial, antiviral and anti-inflammatory activities of different aerial parts (flowers, leaves and seeds) of Datura stramonium. The plant material was extracted ... -
Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1ᵀ
Juhasz, Bertalan; Pech-Puch, Dawrin; Tabudravu, Jioji; Cautain, Bastien; Reyes, Fernando; Jiménez, Carlos; Kyeremeh, Kwaku; Jaspars, Marcel (MDPI, 2021-06-03)[Abstract] Three dermacozines, dermacozines N–P (1–3), were isolated from the piezotolerant Actinomycete strain Dermacoccus abyssi MT 1.1ᵀ, which was isolated from a Mariana Trench sediment in 2006. Herein, we report the ... -
Detection of Aeromonas Salmonicida Subsp. Salmonicida Infection in Zebrafish by Labelling Bacteria With Gfp and a Fluorescent Probe Based on the Siderophore Amonabactin
Rodríguez-Pedrouzo, A.; Cisneros Sureda, Javier; Martínez Matamoros, Diana; Rey-Varela, Diego; Balado, Miguel; Rodríguez, Jaime; Lemos, Manuel L.; Folgueira, Mónica; Jiménez, Carlos (Elsevier, 2023-10-21)[Abstract] Zebrafish (Danio rerio) is an excellent model to study bacterial infections in fish and their treatment. We used zebrafish as a model of infection for Aeromonas salmonicida subsp. salmonicida (hereinafter A. ... -
Dolabelladienols A–C, New Diterpenes Isolated from Brazilian Brown Alga Dictyota pfaffii
Pardo-Vargas, Alonso; Barcelos Oliveira, Ingrid de; Stephens, Paulo Roberto Soares; Cirne-Santos, Claudio Cesar; Palmer Paixão, Izabel Christina Nunes de; Ramos, Freddy Alejandro; Jiménez, Carlos; Rodríguez, Jaime; Resende, Jackson Antonio Lamounier Camargos; Teixeira, Valeria Laneuville; Castellanos, Leonardo (Multidisciplinary Digital Publishing Institute, 2014)[Abstract:]The marine brown alga Dictyota pfaffii from Atol das Rocas, in Northeast Brazil is a rich source of dolabellane diterpene, which has the potential to be used in future antiviral drugs by inhibiting reverse ... -
Enigmazole C: A Cytotoxic Macrocyclic Lactone and Its Ring-Opened Derivatives from a New Species of Homophymia Sponge
Tarazona, G.; Fernández, Rogelio; Pérez, Marta; Millán, Ramón; Jiménez, Carlos; Rodríguez, Jaime; Cuevas, Carmen (American Chemical Society, 2022-03-02)[Abstract] A new macrolide, enigmazole C (1), and two additional analogues, enigmazoles E (2) and D (3), were obtained from a new species of the Homophymia genus as part of an ongoing discovery program at PharmaMar to study ... -
FrpA Is the Outer Membrane Piscibactin Transporter in Vibrio Anguillarum: Structural Elements in Synthetic Piscibactin Analogues Required for Transport
Lages, Marta Afonso; De la Fuente, Carmen; Ageitos, Lucía; Martínez Matamoros, Diana; Rodríguez, Jaime; Balado, Miguel; Jiménez, Carlos; Lemos, Manuel L. (Springer Nature, 2021-11-18)[Abstract] Piscibactin (Pcb) is a labile siderophore widespread among Vibrionaceae. Its production is a major virulence factor of some fish pathogens such as Photobacterium damselae subsp. piscicida and Vibrio anguillarum. ... -
Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D
Alvariño, Rebeca; Alfonso, Amparo; Pech-Puch, Dawrin; Gegunde, Sandra; Rodríguez, Jaime; Vieytes, Mercedes R.; Jiménez, Carlos; Botana, Luis M. (American Chemical Society, 2022-07-28)[Abstract] Neuroprotective properties of five previously described furanoditerpenes 1–5, isolated from Spongia (Spongia) tubulifera, were evaluated in an in vitro oxidative stress model in SH-SY5Y cells. Dose–response ... -
Identification of Key Functions Required for Production and Utilization of the Siderophore Piscibactin Encoded by the High-Pathogenicity Island irp-HPI in Vibrionaceae
Lages, Marta Afonso; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Lemos, Manuel L.; Balado, Miguel (MDPI, 2022)[Abstract] Piscibactin is a widespread siderophore system present in many different bacteria, especially within the Vibrionaceae family. Previous works showed that most functions required for biosynthesis and transport of ... -
In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa
Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-06-23)[Abstract] The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the ... -
In-Depth Analysis of the Role of the Acinetobactin Cluster in the Virulence of Acinetobacter baumannii
Conde-Pérez, Kelly; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Ageitos, Lucía; Rumbo-Feal, Soraya; Martínez-Guitián, Marta; Trigo Tasende, Noelia; Rodríguez, Jaime; Bou, Germán; Jiménez, Carlos; Beceiro, Alejandro; Poza, Margarita (Frontiers, 2021-10-05)[Abstract] Acinetobacter baumannii is a multidrug-resistant pathogen that represents a serious threat to global health. A. baumannii possesses a wide range of virulence factors that contribute to the bacterial pathogenicity. ...
