Browsing by Author "Fernández-Tajes, Juan"
Now showing items 1-12 of 12
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A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)[Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ... -
An exploratory analysis of associations of genetic variation with the efficacy of tocilizumab in severe COVID-19 patients: a pharmacogenetic study based on next-generation sequencing
Durán-Sotuela, Alejandro; Vázquez-García, Jorge; Relaño-Fernández, Sara; Balboa-Barreiro, Vanesa; Fernández-Tajes, Juan; Blanco García, Francisco J; Rego-Pérez, Ignacio (Frontiers, 2024-09-13)[Abstract] Background: In the context of the cytokine storm the takes place in severe COVID-19 patients, the Interleukin 6 (IL6) pathway emerges as one of the key pathways involved in the pathogenesis of this ... -
Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer
Valladares-Ayerbes, Manuel; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Blanco, Moisés; Fernández-Tajes, Juan; Quindós-Varela, María; Carral, Alberto; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (BioMed Central, 2012-09-06)[Abstract] Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ... -
Cytogenetics of the razor clam "Solen marginatus" (Mollusca: Bivalvia: Solenidae)
Fernández-Tajes, Juan; González-Tizón, Ana M.; Martínez-Lage, Andrés; Méndez, Josefina (Karger, 2003)[Abstract:] The razor clam Solen marginatus has a diploid chromosome number of 38. The karyotype consists of one metacentric/submetacentric, three submetacentric/metacentric, five submetacentric, one submetacentric/subtelocentric, ... -
Discovery of circulating proteins associated to knee radiographic osteoarthritis
Lourido Salas, Lucía María; Ayoglu, Burcu; Fernández-Tajes, Juan; Oreiro, Natividad; Henjes, Frauke; Hellström, Cecilia; Schwenk, Jochen M.; Ruiz-Romero, Cristina; Nilsson, Peter; Blanco García, Francisco J (Nature, 2017-03-09)[Abstract] Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for ... -
Genetic Variation of the Razor Clam Ensis Siliqua (Jeffreys, 1875) Along the European Coast Based on Random Amplified Polymorphic DNA Markers
Fernández-Tajes, Juan; Gaspar, Miguel; Martínez-Patiño, Dorotea; McDonough, Niall; Roberts, Dai; González-Tizón, Ana M.; Martínez-Lage, Andrés; Méndez, Josefina (Wiley, 2007-08)[Abstract] Ensis siliqua is regarded as an increasingly valuable fishery resource with potential for commercial aquaculture in many European countries. The genetic variation of this razor clam was analysed by randomly ... -
Genome sizes and karyotypes in the razor clams "Ensis arcuatus" (Jeffreys, 1865) and "E. siliqua" (Linnaeus, 1758)
Fernández-Tajes, Juan; Martínez-Lage, Andrés; Freire, Ruth; Guerra, Alejandro; Méndez, Josefina; González-Tizón, Ana M. (CNRS - Station Biologique de Roscoff- ABiMS, 2008-03)[Abstract] The razor clams Ensis arcuatus and E. siliqua show a diploid DNA content of 3.85 ± 0.049 pg and 4.00 ± 0.050 pg, respectively. Both have a diploid chromosome number of 38 although their karyotypes show remarkable ... -
Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization
Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)[Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ... -
Low Vitamin D Levels and Frailty Status in Older Adults: a Systematic Review and Meta-Analysis
Marcos-Pérez, Diego; Sánchez-Flores, María; Bonassi, Stefano; Costa, Solange; Teixeira, João; Fernández-Tajes, Juan; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (2020)[Abstract] Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low ... -
Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes
Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)[Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ... -
The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Suárez-Ulloa, Victoria; Fernández-Tajes, Juan; Aguiar-Pulido, Vanessa; Rivera-Casas, Ciro; González-Romero, Rodrigo; Ausio, Juan; Méndez, Josefina; Dorado, Julián; Eirín-López, J.M.Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. ... -
The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells
Valdiglesias, Vanessa; Fernández-Tajes, Juan; Méndez, Josefina; Pásaro, Eduardo; Laffon, Blanca (Elsevier, 2013-04-03)[Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ...
