Browsing by Author "Cuezva, José M."

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Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions

Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; García-Herrero, Carmen M.; Sánchez-Aragó, María; Cuezva, José M.; Galindo, María; Bravo, Beatriz; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (Nature, 2017-06-16)

[Abstract] Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms ...