Browsing by Author "Criado, Gabriel"
Now showing items 1-3 of 3
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Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions
Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; García-Herrero, Carmen M.; Sánchez-Aragó, María; Cuezva, José M.; Galindo, María; Bravo, Beatriz; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (Nature, 2017-06-16)[Abstract] Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms ... -
IL6/sIL6R Regulates TNFα-Inflammatory Response in Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms
Valin, Álvaro; Del Rey, Manuel J.; Municio, Cristina; Usategui, Alicia; Romero, Marina; Fernández-Felipe, Jesús; Cañete, Juan D.; Blanco García, Francisco J; Ruano, Yolanda; Criado, Gabriel; Pablos, José L. (BioMed Central, 2020-10-30)[Abstract] Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts ... -
Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; Ergueta, Sandra; Martín, Eduardo; Municio, Cristina; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (BMC, 2019-11-05)[Abstract] Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence ...
