Listar por tema "Genome-wide association study"

Mostrando ítems 1-2 de 2

    • Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept 

      Ferreiro-Iglesias, Aida; Montes, Ariana; Pérez-Pampin, Eva; Cañete, Juan D.; Raya, Enrique; Magro-Checa, César; Vasilopoulos, Yiannis; Cáliz, Rafael; Ferrer, Miguel Ángel; Joven, Beatriz; Carreira, Patricia; Balsa, Alejandro; Pascual-Salcedo, Dora; Blanco García, Francisco J; Moreno-Ramos, Manuel J.; Manrique-Arija, Sara; Ordoñez, María del Carmen; Alegre-Sancho, Juan J.; Narváez, Javier; Navarro-Sarabia, Federico; Moreira, Viriginia; Valor, Lara; García-Portales, Rosa; Márquez, Ana; Gómez-Reino, Juan J.; Martín, Javier; González, Antonio (PLoS, 2019-02-28)
      [Abstract] Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) ...

    • GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways 

      López-Isac, Elena; Acosta-Herrera, Marialbert; Kerick, Martin; Assassi, Shervin; Satpathy, Ansuman T.; Granja, Jeffrey; Mumbach, Maxwell R.; Beretta, Lorenzo; Simeón, Carmen P.; Carreira, Patricia; Ortego-Centeno, Norberto; Castellvi, Iván; Bossini-Castillo, Lara; Carmona, F. David; Orozco, Gisela; Hunzelmann, Nicolas; Distler, Jörg H.W.; Franke, Andre; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Vries-Bouwstra, Jeska de; Wijmenga, Cisca; Koeleman, Bobby P.C.; Nordin, Annika; Padyukov, Leonid; Hoffmann-Vold, Anna-Maria; Lie, Benedicte; Proudman, Susanna; Stevens, Wendy; Nikpour, Mandana; Vyse, Timothy; Herrick, Ariane L.; Worthington, Jane; Denton, Christopher P.; Allarone, Yannick; Brown, Matthew A.; Radstake, Timothy R.D.J.; Fonseca, Carmen; Chang, Howard Y.; Mayes, Maureen D.; Martín, Javier (Nature, 2019-10-31)
      [Abstract] Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous ...