Browsing by Research Group "Xenética de Organismos Mariños (XENOMAR)"
Now showing items 1-9 of 9
-
26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines
It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ... -
A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity Against Colorectal and Triple Negative Breast Cancer Cells
(MDPI, 2020-03-30)[Abstract] A family of compounds with the general formula [Fe(η5-C5H5)(CO)(PPh3)(NCR)]+ has been synthesized (NCR = benzonitrile (1); 4-hydroxybenzonitrile (2); 4-hydroxymethylbenzonitrile (3); 4-aminobenzonitrile (4); ... -
Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: a Promising Approach for Target-Based Cancer Therapy
(American Chemical Society, 2020-09-01)[Abstract] Microtubule affinity-regulating kinase 4 (MARK4), a member of the serine/threonine kinase family, is an emerging therapeutic target in anticancer drug discovery paradigm due to its involvement in regulation of ... -
Genetic characterization of wild, broodstock and seed samples of "Polititapes rhomboides" (Bivalvia: Veneridae): implications for hatchery seed production
(Elsevier, 2021-03-13)[Abstract] The banded carpet shell Polititapes rhomboides is a fishery resource and a suitable candidate for the development of native clam aquaculture in Europe. Here, we analyzed nine microsatellite loci in wild samples ... -
Genetic Variability in Ruditapes Decussatus Clam Combined With Perkinsus Infection Level to Support Founder Population Selection for a Breeding Program
(PeerJ, 2020-10-28)[Abstract] Clam farmers worldwide face several challenges, including irregular seed supply and high mortalities due to pathogenic organisms such as "Perkinsus olseni". In Europe, there is a high unmet consumer demand for ... -
Innovative three-step microwave-promoted synthesis of N-propargyltetrahydroquinoline and 1,2,3-triazole derivatives as a potential factor Xa (FXa) inhibitors: drug design, synthesis, and biological evaluation
(MDPI AG, 2020-01-23)[Abstract]: The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation ... -
RNA-Seq analysis for assessing the early response to DSP toxins in Mytilus galloprovincialis digestive gland and gill
(MDPI, 2018-10-16)[Abstract] The harmful effects of diarrhetic shellfish poisoning (DSP) toxins on mammalian cell lines have been widely assessed. Studies in bivalves suggest that mussels display a resistance to the cytogenotoxic effects ... -
The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. ... -
Therapeutic Potential of Vanadium Complexes With 1,10-Phenanthroline Ligands, Quo Vadis? Fate of Complexes in Cell Media and Cancer Cells
(Elsevier, 2021-01-11)[Abstract] VⁱᵛO-complexes formulated as [VⁱᵛO(OSO₃)(phen)₂] (1) (phen = 1,10-phenanthroline), [VⁱᵛO(OSO₃)(Me₂phen)₂] (2) (Me₂phen = 4,7-dimethyl-1,10-phenanthroline) and [VⁱᵛO(OSO₃)(amphen)₂] (3) (amphen = 5-amino-1,10-p ...
