• Advancements in the fight against globally distributed OXA-48 carbapenemase: evaluating the new generation of carbapenemase inhibitors 

      Outeda-García, Michelle; Arca-Suárez, Jorge; Lence, Emilio; Rodríguez-Coello, Arianna; Maceiras, Romina; Blanco-Martín, Tania; Guijarro-Sánchez, Paula; González-Pinto, Lucía; Alonso-García, Isaac; García-Pose, Andrea; Muras, Andrea; Rodríguez-Pallares, Salud; Lasarte-Monterrubio, Cristina; González-Bello, Concepción; Vázquez-Ucha, Juan Carlos; Bou, Germán; Beceiro Casas, Alejandro (American Society of Microbiology, 2025-01-10)
      [Abstract] Carbapenemase OXA-48 and its variants pose a serious threat to the development of effective treatments for bacterial infections. OXA-48-producing Enterobacterales are the most prevalent carbapenemase-producing ...
    • In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes 

      Rodríguez-Pallares, Salud; Blanco-Martín, Tania; Lence, Emilio; Aja-Macaya, Pablo; Sánchez-Peña, Lucía; González-Pinto, Lucía; Rodríguez-Mayo, María; Fernández-González, Ana; Galán-Sánchez, Fátima; Beceiro, Alejandro; González-Bello, Concepción; Bou, Germán; Arca-Suárez, Jorge (American Society of Microbiology, 2024-11-06)
      [Abstract] We describe the in vivo emergence of resistance to ceftazidime/avibactam via modification of AmpC in a clinical Klebsiella aerogenes isolate during therapy with this combination. Paired ceftazidime/avibactam-s ...