• In-hospital postoperative infection after heart transplantation: risk factors and development of a novel predictive score 

      Fernández-Ugidos, Paula; Barge-Caballero, Eduardo; Gómez-López, Rocío; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Solla-Buceta, Miguel; Iglesias-Gil, Carmen; Aller-Fernández, Vanesa; González-Barbeito, Miguel; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2019-05-11)
      [Abstract] Introduction: Infection is one of the most significant complications following heart transplantation (HT). The aim of this study was to identify specific risk factors for early postoperative infections in HT ...
    • Incidence, Risk Factors and Prognostic Impact of Cytomegalovirus Infection After Heart Transplantation 

      Méndez-Eirín, Elizabet; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Grille Cancela, Zulaika; Blanco-Canosa, Paula; Cañizares-Castellanos, Angelina; González Barbeito, Miguel; Aller Fernández, Ana Vanesa; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2020-03-20)
      [Abstract] Introduction and objectives. To assess the risk factors of CMV infection after heart transplant (HT) and its influence on long-term prognosis. Methods. We conducted a retrospective single-centre study of ...
    • Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation 

      Suárez-Fuentetaja, Natalia; Doménech, Nieves; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Barge-Caballero, Eduardo; Grille Cancela, Zulaika; Pombo-Otero, Jorge; Muñiz, Javier; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier, 2012-11-10)
      [Abstract] Background. The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO ...
    • Is Becker dystrophinopathy a contraindication to heart transplant?: experience in a single institution 

      Ascencio-Lemus, Marisol Guadalupe; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Crespo-Leiro, María Generosa (Elsevier, 2018-07-17)
    • Light Chain and Transthyretin Cardiac Amyloidosis: Clinical Characteristics, Natural History and Prognostic Factors 

      Barge-Caballero, Gonzalo; Vázquez-García, Raquel; Barge-Caballero, Eduardo; Couto-Mallón, David; Paniagua-Martín, María J.; Barriales-Villa, Roberto; Piñón-Esteban, Pablo; Bouzas-Mosquera, Alberto; Pombo-Otero, Jorge; Debén-Ariznavarreta, Guillermo; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2021-03-13)
      [Abstract] Introduction and objectives. Light-chain amyloidosis (AL-CA) and transthyretin amyloidosis (ATTR-CA) are the most common types of cardiac amyloidosis (CA). We sought to study the clinical characteristics and ...
    • Long-term results of heart transplant in recipients older and younger than 65 years: a comparative study of mortality, rejections, and neoplasia in a cohort of 445 patients 

      Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Muñiz, Javier; Marzoa Rivas, Raquel; Piñón-Esteban, Pablo; Rodríguez-Fernández, José Ángel; Hermida, L.F.; Calviño-Santos, Ramón; Cuenca, José J.; Juffé-Stein, Alberto; Castro-Beiras, Alfonso (Elsevier, 2005-12-28)
      [Resumen] Background. Whether being older than 65 years should be considered an absolute counterindication to heart transplant (HT), as it is in some centers, is controversial. In our centre, patients older than 65 years ...
    • Lung cancer after heart transplantation: results from a large multicenter registry 

      Crespo-Leiro, María Generosa; Villa-Arranz, Adolfo; Manito-Lorite, Nicolás; Paniagua-Martín, María J.; Rábago, Gregorio; Almenar-Bonet, Luis; Alonso-Pulpón, Luis; Mirabet, Sonia; Díaz Molina, Beatriz; González-Vílchez, Francisco; Arizón-del-Prado, José M.; Romero-Rodríguez, N.; Delgado-Jiménez, Juan F.; Roig, Eulàlia; Blasco-Peiró, Teresa; Pascual Figal, Domingo A.; De la Fuente-Galán, Luis; Muñiz, Javier (Wiley, 2011-04-26)
      [Abstract] In this study we analyzed Spanish Post-Heart-Transplant Tumour Registry data for adult heart transplantation (HT) patients since 1984. Median post-HT follow-up of 4357 patients was 6.7 years. Lung cancer (mainly ...
    • Microchimerism after heart transplantation: prevalence, predisposing factors, natural history, and prognosis 

      Crespo-Leiro, María Generosa; Hermida-Prieto, Manuel; Rodríguez-Fernández, José Ángel; Muñiz, Javier; Barral, S.; Paniagua-Martín, María J.; Hermida, L.F.; Juffé-Stein, Alberto; Castro-Beiras, Alfonso (Elsevier, 2002-04-10)
    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...
    • Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (PLoS, 2012-08-28)
      [Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...
    • Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders 

      Martínez-Paz, E.; Barge-Caballero, Eduardo; Álvarez-Roy, Laura; Barge-Caballero, Gonzalo; Couto-Mallón, David; Paniagua-Martín, María J.; Mosquera-Pérez, Ignacio; Pérez-Álvarez, Luisa; Muñiz, Javier; Cuenca-Castillo, José J.; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2017-12-13)
    • Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection 

      Marrón Liñares, Grecia Manuela; Núñez, Lucía; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Pombo-Otero, Jorge; Paniagua-Martín, María J.; Suárez-Fuentetaja, Natalia; Cid, Javier; Grille Cancela, Zulaika; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel; Hermida-Prieto, Manuel (Elsevier, 2017-07-15)
      [Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). ...
    • Prevalence and severity of renal dysfunction among 1062 heart transplant patients according to criteria based on serum creatinine and estimated glomerular filtration rate: results from the CAPRI study 

      Crespo-Leiro, María Generosa; Delgado-Jiménez, Juan F.; Paniagua-Martín, María J.; Vázquez de Prada, José A.; Fernández-Yáñez, Juan; Almenar-Bonet, Luis; Díaz Molina, Beatriz; Roig, Eulàlia; Arizón-del-Prado, José M.; Alonso-Pulpón, Luis; Garrido, Iris P.; Sanz-Julve, Marisa; De la Fuente-Galán, Luis; Mirabet, Sonia; Manito-Lorite, Nicolás; Muñiz, Javier (Wiley, 2009-12-18)
      [Abstract] Chronic kidney disease (CKD) is staged on the basis of glomerular filtration rate; generally, the MDRD study estimate, eGFR, is used. Renal dysfunction (RD) in heart transplant (HT) patients is often evaluated ...
    • Prevalence of tricuspid regurgitation after orthotopic heart transplantation and its evolution in the follow-up period: a long-term study 

      López-Vilella, Raquel; Paniagua-Martín, María J.; González-Vílchez, Francisco; Donoso Trenado, Víctor; Barge-Caballero, Eduardo; Sánchez-Lázaro, Ignacio; Aller Fernández, Ana Vanesa; Martínez-Dolz, Luis; Crespo-Leiro, María Generosa; Almenar-Bonet, Luis (Elsevier, 2022-10-26)
      [Abstract] Background. Tricuspid regurgitation (TR) after heart transplant (HT) can be an important complication depending on its etiology and severity. This study aims to analyze the prevalence of TR, the causes, and its ...
    • Prognostic significance of heart rate and its long-term trend in cardiac transplant patients 

      Barge-Caballero, Eduardo; Jiménez-López, Jesús; Chávez-Leal, Sergio; Barge-Caballero, Gonzalo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Cuenca-Castillo, José J.; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier para Sociedad Española de Cardiología, 2015-04-11)
      [Abstract] Introduction and objectives. The aim of the present study was to examine the prognostic significance of heart rate and its trend in heart transplantation. Methods. This observational study enrolled 170 patients ...
    • Prognostic value of the nutritional risk index in heart transplant recipients 

      Barge-Caballero, Eduardo; García-López, Fernando; Marzoa Rivas, Raquel; Barge-Caballero, Gonzalo; Couto-Mallón, David; Paniagua-Martín, María J.; Solla-Buceta, Miguel; Velasco-Sierra, Carlos; Pita-Gutiérrez, Francisco; Herrera-Noreña, José M.; Cuenca-Castillo, José J.; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier para Sociedad Española de Cardiología, 2017-02-10)
      [Abstract] Introduction and objectives. To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation ...
    • Quinolone-related Achilles tendinopathy in heart transplant patients: incidence and risk factors 

      Barge-Caballero, Eduardo; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Muñiz, Javier; Naya, Carmen; Bouzas-Mosquera, Alberto; Piñón-Esteban, Pablo; Marzoa Rivas, Raquel; Pazos-López, Pablo; Cursack, Guillermo C.; Cuenca-Castillo, José J.; Castro-Beiras, Alfonso (Elsevier, 2008-01-08)
      [Abstract] Background. A high incidence of Achilles tendinopathy—tendinitis or rupture—has been observed after quinolone treatment in lung and kidney transplant patients. In the absence of relevant published data, we aimed ...
    • Real World Comparison of Spironolactone and Eplerenone in Patients With Heart Failure 

      Pardo-Martínez, Patricia; Barge-Caballero, Eduardo; Bouzas-Mosquera, Alberto; Barge-Caballero, Gonzalo; Couto-Mallón, David; Paniagua-Martín, María J.; Sagastagoitia-Fornie, Marta; Prada-Delgado, Óscar; Muñiz, Javier; Almenar-Bonet, Luis; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2022-01-06)
      [Abstract] Aims. In the absence of previous direct comparative studies, we aimed to evaluate the effectiveness of spironolactone and eplerenone in patients with heart failure and reduced ejection fraction (HFrEF) in a ...
    • Renal dysfunction after orthotopic heart transplantation: incidence, natural history, and risk factors 

      Garrido, Iris P.; Crespo-Leiro, María Generosa; Muñiz, Javier; Rodríguez-Fernández, José Ángel; Regueiro, M.; Vázquez-Rey, E.; Castro-Beiras, Alfonso; Paniagua-Martín, María J. (Elsevier, 2003-08-30)
      [Abstract] Background. Renal dysfunction is a common complication after orthotopic heart transplantation (HT). The importance of factors other than exposure to immunosuppressive drugs is unclear. The purpose of this study ...
    • Risk factors associated with moderate-to-severe renal dysfunction among heart transplant patients: results from the CAPRI study 

      Delgado-Jiménez, Juan F.; Crespo-Leiro, María Generosa; Gómez-Sánchez, Miguel A.; Paniagua-Martín, María J.; González-Vílchez, Francisco; Vázquez de Prada, José A.; Fernández-Yáñez, Juan; Pascual, David; Almenar-Bonet, Luis; Martínez-Dolz, Luis; Díaz Molina, Beatriz; Roig, Eulàlia; Segovia Cubero, Javier; Arizón-del-Prado, José M.; Garrido, Iris P.; Blasco-Peiró, Teresa; López, Javier; Brossa-Loidi, Vicens; Manito-Lorite, Nicolás; Muñiz, Javier (Wiley, 2010-06-27)
      [Abstract] The longer survival of patients with heart transplantation (HT) favors calcineurin inhibitor–related chronic kidney disease (CKD). It behoves to identify risk factors. At 14 Spanish centers, data on 1062 adult ...