Browsing by Author "Méndez, Josefina"
Now showing items 21-38 of 38
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Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization
Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)[Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ... -
Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type
Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Méndez, Josefina (Elsevier, 2011-03-01)[Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ... -
Introducción
Méndez, Josefina; Cerdán, María Esperanza; Rodríguez, Ana (Universidade da Coruña, 1994) -
Karyotypes and Ag-NORs of the mussels Mytilus californianus and M. trossulus from the Pacific Canadian coast
Martínez-Lage, Andrés; González-Tizón, Ana M.; Ausió, Juan; Méndez, Josefina (Elsevier, 1997-01-01)[Abstract] The karyotypes and the nucleolus organizer regions (NORs) of “M. californianus” and “M. trossulus” from the Pacific coast are reported here for the first time. The karyotypes show seven metacentric and seven ... -
Molecular and evolutionary analysis of mussel histone genes ("Mytilus" spp.): possible evidence of an "orphon origin" for H1 histone genes
Eirín-López, J.M.; González-Tizón, Ana M.; Martínez-Lage, Andrés; Méndez, Josefina (Springer Nature, 2002-09)[Abstract:] Linker histones are a divergent group of histone proteins with an independent evolutionary history in which, besides somatic subtypes, tissue- and differentiation-specific subtypes are included. In the present ... -
Molecular evolutionary characterization of the mussel "Mytilus" histone multigene family: first record of a tandemly repeated unit of five histone genes containing an H1 subtype with orphon features
Eirín-López, J.M.; Ruiz Lorenzo, María Fernanda; González-Tizón, Ana M.; Martínez-Lage, Andrés; Sánchez Rodríguez, Lucas; Méndez, Josefina (Springer Nature, 2004-02)[Abstract] The present work represents the first characterization of a clustered histone repetitive unit containing an H1 gene in a bivalve mollusk. To complete the knowledge on the evolutionary history of the histone ... -
Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types
Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Royal Society of Chemistry (Gran Bretaña), 2011-03-28)[Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ... -
Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates
Prego-Faraldo, María Verónica; Valdiglesias, Vanessa; Méndez, Josefina; Eirín-López, J.M. (Multidisciplinary Digital Publishing Institute, 2013)Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination in the oceans, producing high concentrations of potentially harmful biotoxins that are accumulated across the food chains. One such ... -
Okadaic Acid: More than a Diarrheic Toxin
Valdiglesias, Vanessa; Prego-Faraldo, María Verónica; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Multidisciplinary Digital Publishing Institute, 2013)Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary ... -
Origin and evolution of "Mytilus" mussel satellite DNAs
Martínez-Lage, Andrés; Rodríguez Fariña, María Fernanda; González-Tizón, Ana M.; Méndez, Josefina (Canadian Science Publishing, 2005-04)[Abstract] A phylogenetic reconstruction based on the amplification of 3 satellite DNAs (stDNAs) was carried out in 1 crustacean species and 15 bivalve species of the subclass Pteriomorphia (10, subfamily Mytilinae; 1, ... -
Polyploidy in a Natural Population of Mussel, Mytilus Trossulus
González-Tizón, Ana M.; Martínez-Lage, Andrés; Ausió, Juan; Méndez, Josefina (Canadian Science Publishing, 2000-03)[Abstract] We have analyzed natural polyploidy in a population of “Mytilus trossulus” from Vancouver Island (British Columbia, Canada) by means of cytogenetic techniques. Results obtained are the first reporting on this ... -
Relationship Between Structure and Cytotoxicity of Vanadium and Molybdenum Complexes With Pyridoxal Derived Ligands
Mato-López, Lucía; Sar-Rañó, Antía; Riopedre-Fernández, Miguel; Díaz, María Luz; Gil, Adrià; Sánchez-González, Ángel; Fernández-Bertólez, Natalia; Méndez, Josefina; Valdiglesias, Vanessa; Avecilla, Fernando (Elsevier, 2022-07-14)[Abstract] In this work four vanadium complexes (compounds 1, 2, 3 and 4) and one molybdenum complex (compound 5) with hydrazone ligands derived from pyridoxal were synthesized and characterized. All compounds are mononuclear ... -
RNA-Seq analysis for assessing the early response to DSP toxins in Mytilus galloprovincialis digestive gland and gill
Prego-Faraldo, María Verónica; Martínez Martínez, M. Luisa; Méndez, Josefina (MDPI, 2018-10-16)[Abstract] The harmful effects of diarrhetic shellfish poisoning (DSP) toxins on mammalian cell lines have been widely assessed. Studies in bivalves suggest that mussels display a resistance to the cytogenotoxic effects ... -
Sequence characterization of the 5S ribosomal DNA and the internal transcribed spacer (ITS) region in four European Donax species (Bivalvia: Donacidae)
Méndez, Josefina; Nantón, Ana; Fernández-Pérez, Jenyfer (BioMed Central, 2018)[Abstract] Background: The whole repeat unit of 5S rDNA and the internal transcribed spacer (ITS) of four European Donax species were analysed. After amplifying, cloning and sequencing several 5S and ITS units, their basic ... -
Telomeric localization of the vertebrate-type hexamer repeat, (TTAGGG) ₙ, in the wedgeshell clam "Donax trunculus" and other marine invertebrate genomes
Plohl, Miroslav; Prats, Eva; Martínez-Lage, Andrés; González-Tizón, Ana M.; Méndez, Josefina; Cornudella, Luis (American Society for Biochemistry and Molecular Biology, 2002-05-31)[Abstract]: The hexamer repeat sequence (TTAGGG) n, found at the ends of all vertebrate chromosomes, was previously identified as the main building element of one member of aHindIII satellite DNA family characterized in ... -
The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Suárez-Ulloa, Victoria; Fernández-Tajes, Juan; Aguiar-Pulido, Vanessa; Rivera-Casas, Ciro; González-Romero, Rodrigo; Ausio, Juan; Méndez, Josefina; Dorado, Julián; Eirín-López, J.M.Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. ... -
The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells
Valdiglesias, Vanessa; Fernández-Tajes, Juan; Méndez, Josefina; Pásaro, Eduardo; Laffon, Blanca (Elsevier, 2013-04-03)[Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ... -
The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes
Laffon, Blanca; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina (Springer, 2009-05-08)[Abstract] The objective of this work was to evaluate the effects of selenomethionine (SeMet) on the induction, repair, and persistence of DNA damage in human leukocytes challenged with bleomycin (BLM). Comet assay was ...
