• Feedback control of stochastic gene switches using PIDE models 

      Fernández, Christian; Faquir, Hamza; Pájaro Diéguez, Manuel; Otero-Muras, Irene (Elsevier, 2022)
      [Abstract]: Achieving control of gene regulatory circuits is one of the goals of synthetic biology, as a way to regulate cellular functions for useful purposes (in biomedical, environmental or industrial applications). The ...
    • First passage times as a measure of hysteresis in stochastic gene regulatory circuits 

      Pájaro Diéguez, Manuel; Otero-Muras, Irene; Alonso, Antonio A. (Elsevier, 2022)
      [Abstract]: In the context of phenotype switching and cell fate determination, numerousexperimental studies report hysteresis, despite the fact that the (forward) Chemical Master Equation governing the inherently stochastic ...