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Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
(Frontiers, 2021)
[Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding ...
Epigenetic Landscape in Blood Leukocytes Following Ketosis and Weight Loss Induced by a Very Low Calorie Ketogenic Diet (VLCKD) in Patients With Obesity
(Elsevier, 2021)
[Abstract] Background:The molecular mechanisms underlying the potential health benefits of a ketogenic diet areunknown and could be mediated by epigenetic mechanisms.Objective:To identify the changes in the obesity-related ...
npcure: An R Package for Nonparametric Inference in Mixture Cure Models
(Technische Universitaet Wien, 2021)
[Abstract] Mixture cure models have been widely used to analyze survival data with a cure fraction. They assume that a subgroup of the individuals under study will never experience the event (cured subjects). So, the goal ...
Altered pathways in methylome and transcriptome longitudinal analysis of normal weight and bariatric surgery women
(NLM (Medline), 2020-04-15)
[Abstract] DNA methylation could provide a link between environmental, genetic factors and weight control and can modify gene expression pattern. This study aimed to identify genes, which are differentially expressed and ...
Of Fears and Budgets: Strategies of Control in Vespa velutina Invasion and Lessons for Best Management Practices
(Springer, 2022)
[Abstrat] Implementing management practices for the control of invasive species can be a complex task with multiple dimensions, where the identification of stakeholders and drivers of those practices is of paramount ...
DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se
(Springer Nature, 2019-05-27)
[Abstract]
Background/objectives: Obesity has been associated with gene methylation regulation. Recent studies have shown that epigenetic signature plays a role in metabolic homeostasis after Roux-en Y gastric bypass ...
Nonparametric Kernel Estimation of the Probability of Cure in a Mixture Cure Model when the Cure Status is Partially Observed
(Sage, 2022-08-01)
[Abstract] Cure models are a class of time-to-event models where a proportion of individuals will never experience the event of interest. The lifetimes of these so-called cured individuals are always censored. It is usually ...
Estimating Lengths-Of-Stay of Hospitalized COVID-19 Patients Using a Non-parametric Model: A Case Study in Galicia (Spain)
(Cambridge University Press, 2021)
[Abstract] Estimating the lengths-of-stay (LoS) of hospitalised COVID-19 patients is key for predicting the hospital beds’ demand and planning mitigation strategies, as overwhelming the healthcare systems has critical ...
Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study
(Frontiers Media S.A., 2023-02-08)
[Abstract]: Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the ...
Estimation of patient flow in hospitals using up-to-date data. Application to bed demand prediction during pandemic waves
(PLOS, 2023-02-27)
[Abstract] Hospital bed demand forecast is a first-order concern for public health action to avoid healthcare systems to be overwhelmed. Predictions are usually performed by estimating patients flow, that is, lengths of ...