Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, via electrophilic fluorination of lithiated bis-lactim ethers
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Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, via electrophilic fluorination of lithiated bis-lactim ethersDate
2002-06-25Citation
Ruiz, M.; Ojea, V.; Quintela, J. M.; Guillín, J. J. Chem. Commun. 2002, 1600-1601
Abstract
[Abstract] Electrophilic fluorinations of lithiated bis-lactim ethers derived from cyclo-[L-AP4-D-Val] allow a direct access to alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, in enantiomerically pure form and suitable protected for solid-phase peptide synthesis.
Keywords
Phosphonate mimetics
Phosphoserine
Phosphothreonine
Electrophilic fluorination
Bis-lactim ethers
Amino acid
Phosphoserine
Phosphothreonine
Electrophilic fluorination
Bis-lactim ethers
Amino acid
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ISSN
1359-7345