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Effects of Iron Oxide Nanoparticles: Cytotoxicity, Genotoxicity, Developmental Toxicity, and Neurotoxicity

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Valdiglesias_Vanessa_2015_Effects_iron_oxide_nanoparticles.pdf (338.8Kb)
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http://hdl.handle.net/2183/39931
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  • Investigación (FEDU) [938]
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Título
Effects of Iron Oxide Nanoparticles: Cytotoxicity, Genotoxicity, Developmental Toxicity, and Neurotoxicity
Autor(es)
Valdiglesias, Vanessa
Kiliç, Gözde
Costa, C.
Fernández-Bertólez, Natalia
Pásaro, Eduardo
Teixeira, Joao
Laffon, Blanca
Data
2014-08-22
Cita bibliográfica
Valdiglesias, V., Kiliç, G., Costa, C., Fernández-Bertólez, N., Pásaro, E., Teixeira, J.P. and Laffon, B. (2015), Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity. Environ. Mol. Mutagen., 56: 125-148. https://doi.org/10.1002/em.21909
Resumo
[Abstract] Iron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Increasing potential applications raise concerns over their potential effects on human health. Nevertheless, very little is currently known about the toxicity associated with exposure to these nanoparticles at different levels of biological organization. This article provides an overview of recent studies evaluating ION cytotoxicity, genotoxicity, developmental toxicity and neurotoxicity. Although the results of these studies are sometimes controversial, they generally indicate that surface coatings and particle size seem to be crucial for the observed ION-induced effects, as they are critical determinants of cellular responses and intensity of effects, and influence potential mechanisms of toxicity. The studies also suggest that some ION are safe for certain biomedical applications, while other uses need to be considered more carefully. Overall, the available studies provide insufficient evidence to fully assess the potential risks for human health related to ION exposure. Additional research in this area is required including studies on potential long-term effects.
Palabras chave
Iron oxide nanoparticles
Cytotoxicity
Genotoxicity
Developmental toxicity
Neurotoxicity
 
Descrición
This is the peer reviewed version of the article, which has been published in final form at https://doi.org/10.1002/em.21909.
Versión do editor
https://doi.org/10.1002/em.21909
Dereitos
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
ISSN
1098-2280

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