Site-Selective C–H Amination of Phenol-Containing Biomolecules
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Site-Selective C–H Amination of Phenol-Containing BiomoleculesAutor(es)
Data
2023-06-07Cita bibliográfica
Girón-Elola, C.; Sasiain, I.; Sánchez-Fernández, R.; Pazos, E.; Correa, A. Site-Selective C–H Amination of Phenol-Containing Biomolecules. Org. Lett. 2023, 25 (23), 4383–4387. https://doi.org/10.1021/acs.orglett.3c01560.
Resumo
[Abstract] A C–N bond-forming cross-dehydrogenative coupling of a collection of Tyr-containing peptides and estrogens with heteroarenes is described. This oxidative coupling is distinguished by its scalability, operational simplicity, and air tolerance and enables the appendance of phenothiazines and phenoxazines in phenol-like compounds. When incorporated into a Tb(III) metallopeptide, the Tyr-phenothiazine moiety acts as a sensitizer for the Tb(III) ion, providing a new tool for the design of luminescent probes.
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Dereitos
Atribución 3.0 España
ISSN
1523-7052
1523-7060
1523-7060