Multi-omics approach reveals prebiotic and potential antioxidant effects of essential oils from the mediterranean diet on cardiometabolic disorder using humanized gnotobiotic mice
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Multi-omics approach reveals prebiotic and potential antioxidant effects of essential oils from the mediterranean diet on cardiometabolic disorder using humanized gnotobiotic miceAutor(es)
Data
2023-08-20Cita bibliográfica
Sánchez-Quintero MJ, Delgado J, Martín Chaves L, Medina-Vera D, Murri M, Becerra-Muñoz VM, Estévez M, Crespo-Leiro MG, Paz López G, González-Jiménez A, G Ranea AJ, Queipo-Ortuño MI, Plaza-Andrades I, Rodríguez-Capitán J, Pavón-Morón FJ, Jiménez-Navarro MF. Multi-omics approach reveals prebiotic and potential antioxidant effects of essential oils from the mediterranean diet on cardiometabolic disorder using humanized gnotobiotic mice. Antioxidants (Basel). 2023 Aug 20;12(8):1643.
Resumo
[Abstract] Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary objective of this study was to assess the influences exerted by essential oils derived from thyme (Thymus vulgaris) and oregano (Origanum vulgare) via a comprehensive multi-omics approach within a gnotobiotic murine model featuring colonic microbiota acquired from patients diagnosed with coronary artery disease (CAD) and type-2 diabetes mellitus (T2DM). Our findings demonstrated prebiotic and potential antioxidant effects elicited by these essential oils. We observed a substantial increase in the relative abundance of the Lactobacillus genus in the gut microbiota, accompanied by higher levels of short-chain fatty acids and a reduction in trimethylamine N-oxide levels and protein oxidation in the plasma. Moreover, functional enrichment analysis of the cardiac tissue proteome unveiled an over-representation of pathways related to mitochondrial function, oxidative stress, and cardiac contraction. These findings provide compelling evidence of the prebiotic and antioxidant actions of thyme- and oregano-derived essential oils, which extend to cardiac function. These results encourage further investigation into the promising utility of essential oils derived from herbs commonly used in the Mediterranean diet as potential nutraceutical interventions for mitigating chronic diseases linked to CAD and T2DM.
Palabras chave
Antioxidant
Carbonyl
Coronary artery disease
Diabetes mellitus
Essential oil
Mediterranean diet
Microbiota
Omics
Oregano
Thyme
Carbonyl
Coronary artery disease
Diabetes mellitus
Essential oil
Mediterranean diet
Microbiota
Omics
Oregano
Thyme
Versión do editor
Dereitos
Atribución 3.0 España
ISSN
2076-3921