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dc.contributor.authorBessa, Maria João
dc.contributor.authorBrandão, Fátima
dc.contributor.authorRosário, Fernanda
dc.contributor.authorMoreira, Luciana Maria Vaz
dc.contributor.authorReis, Ana Teresa
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.contributor.authorFraga, S.
dc.contributor.authorTeixeira, Joao
dc.date.accessioned2023-05-04T19:33:54Z
dc.date.available2023-05-04T19:33:54Z
dc.date.issued2023-01-24
dc.identifier.citationMaria João Bessa, Fátima Brandão, Fernanda Rosário, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga & João Paulo Teixeira (2023) Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models, Journal of Toxicology and Environmental Health, Part B, 26:2, 67-96, DOI: 10.1080/10937404.2023.2166638es_ES
dc.identifier.issn1521-6950
dc.identifier.urihttp://hdl.handle.net/2183/33009
dc.description.abstract[Abstract] Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.es_ES
dc.description.sponsorshipThe work was supported by the Fundação para a Ciência e a Tecnologia [POCI-01-0145-FEDER-029651, SFRH/BPD/122112/2016,PTDC/MED‐TOX/31162/2017, DL-57/INSA-06/2018,SFRH/BD/101060/2014,SFRH/BD/120646/2016,SIINN/0004/2014,UIDB/04750/2020, LA/P/0064/2020]; Spanish Ministry of Education, Culture and Sport [BEAGAL18/00142]; Spanish Ministry of Science and Innovation [PID2020-114908GA-I00]es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; POCI-01-0145-FEDER-029651es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; SFRH/BPD/122112/2016es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; PTDC/MED‐TOX/31162/2017es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; DL-57/INSA-06/2018es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; SFRH/BD/101060/2014es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; SFRH/BD/120646/2016es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; SIINN/0004/2014es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; UIDB/04750/2020es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; LA/P/0064/2020es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BEAGAL18%2F00142/ES/es_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114908GA-I00/ES/EVALUACION DEL RIESGO ASOCIADO A LA EXPOSICION A NANOMATERIALES: ESTRATEGIAS TOXICOLOGICAS IN VITRO, IN VIVO E IN SILICO/es_ES
dc.relation.urihttps://doi.org/10.1080/10937404.2023.2166638es_ES
dc.rightsAtribución 4.0 Internacionales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNanoparticleses_ES
dc.subjectRespiratory modelses_ES
dc.subjectIn vitroes_ES
dc.subjectSubmerged cultureses_ES
dc.subjectAir-liquid interfacees_ES
dc.subjectToxicity testinges_ES
dc.titleAssessing the in Vitro Toxicity of Airborne (Nano)Particles to the Human Respiratory System: From Basic to Advanced Models [Review]es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleJournal of Toxicology and Environmental Health. Part B, Critical Reviewses_ES
UDC.volume26es_ES
UDC.issue2es_ES
UDC.startPage67es_ES
UDC.endPage96es_ES
dc.identifier.doi10.1080/10937404.2023.2166638


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