Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study
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Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory studyAutor(es)
Fecha
2023-02-08Cita bibliográfica
Nicoletti CF, Roschel H, Merege-Filho C, Lima AP, Gil S, Pinhel MAS, Noronha NY, Santo MA, Jacome A, Crujeiras AB, Gualano B and Nonino CB (2023) Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study. Front. Sports Act. Living 5:1092050. doi: 10.3389/fspor.2023.1092050
Resumen
[Abstract]: Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. In this exploratory, quasi-experimental study, we analyzed DNA methylation levels by array technology in eleven women who underwent Roux-en-Y Gastric Bypass and a 6-month, three-times-a-week, supervised exercise training program. Epigenome Wide Association Analysis showed 722 CpG sites with different methylation level equal to or greater than 5% (P < 0.01) after exercise training. Some of these CpGs sites were related to pathophysiological mechanisms of inflammation, specially Th17 cell differentiation (FDR value < 0.05 and P < 0.001). Our data showed epigenetic modification in specific CpG sites related to Th17 cell differentiation pathway in post-bariatric women following a 6-months exercise training program.
Palabras clave
DNA methylation
epigenetic
exercise program
obesity
th7 cell differentiation
epigenetic
exercise program
obesity
th7 cell differentiation
Versión del editor
Derechos
Atribución 3.0 España
ISSN
2624-9367