Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula
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http://hdl.handle.net/2183/30947
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- GI- Quimolmat - Artigos [104]
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Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán PeninsulaAutor(es)
Data
2022-04-28Cita bibliográfica
Pech-Puch, D.; Forero, A.M.; Fuentes-Monteverde, J.C.; Lasarte-Monterrubio, C.; Martinez-Guitian, M.; González-Salas, C.; Guillén-Hernández, S.; Villegas-Hernández, H.; Beceiro, A.; Griesinger, C.; Rodríguez, J.; Jiménez, C. Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula. Mar. Drugs 2022, 20, 298. https://doi.org/10.3390/md20050298
Resumo
[Abstract] Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and (+)-agelasidine C (6), were isolated from the sponge Agelas citrina, collected on the coasts of the Yucatán Peninsula (Mexico). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, HRESIMS techniques, and a comparison with literature data. Although the synthesis of (+)-ent-agelasine F (4) has been previously reported, this is the first time that it was isolated as a natural product. The evaluation of the antimicrobial activity against the Gram-positive pathogens Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis showed that all of them were active, with (+)-10-epiagelasine B (2) being the most active compound with an MIC in the range of 1–8 µg/mL. On the other hand, the Gram-negative pathogenes Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae were also evaluated, and only (+)-agelasine B (5) showed a moderate antibacterial activity with a MIC value of 16 μg/mL.
Palabras chave
Diterpene alkaloids
Agelasines
Agelasidines
Marine sponge
Agelas citrina
Antibacterial
Agelasines
Agelasidines
Marine sponge
Agelas citrina
Antibacterial
Versión do editor
Dereitos
Atribución 4.0 Internacional
ISSN
1660-3397