Mostrar o rexistro simple do ítem

Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells [Review]

dc.contributor.authorQuiroga Fernández, Macarena
dc.contributor.authorRodríguez-Alonso, Andrea
dc.contributor.authorAlfonsín Rey, María Gloria
dc.contributor.authorEscuder-Rodríguez, Juan-José
dc.contributor.authorBreijo, Sara M.
dc.contributor.authorChantada, Venancio
dc.contributor.authorFigueroa, Angélica
dc.date.accessioned2022-05-18T09:10:39Z
dc.date.available2022-05-18T09:10:39Z
dc.date.issued2022-02-16
dc.identifier.citationQuiroga, M.; Rodríguez-Alonso, A.; Alfonsín, G.; Rodríguez, J.J.E.; Breijo, S.M.; Chantada, V.; Figueroa, A. Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells. Cancers 2022, 14, 990. https://doi.org/10.3390/cancers14040990es_ES
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/2183/30683
dc.descriptionThe aim of this review was to discuss the fundamental role of E3 ubiquitin ligases in controlling cancer stem cells. It will be surmised that protein degradation controlled by the E3 ubiquitin ligases plays a fundamental role in the self-renewal, maintenance and differentiation of cancer stem cells, highlighting its potential as an effective therapeutic target for anticancer drug development.es_ES
dc.description.abstract[Abstract] Cancer stem cells are a small subpopulation within the tumor with high capacity for self-renewal, differentiation and reconstitution of tumor heterogeneity. Cancer stem cells are major contributors of tumor initiation, metastasis and therapy resistance in cancer. Emerging evidence indicates that ubiquitination-mediated post-translational modification plays a fundamental role in the maintenance of cancer stem cell characteristics. In this review, we will discuss how protein degradation controlled by the E3 ubiquitin ligases plays a fundamental role in the self-renewal, maintenance and differentiation of cancer stem cells, highlighting the possibility to develop novel therapeutic strategies against E3 ubiquitin ligases targeting CSCs to fight cancer.es_ES
dc.description.sponsorshipThis work has been supported by Plan Estatal I + D + I 2013−2016, co-funded by the Instituto de Salud Carlos III (ISCIII, Spain) under grant agreements (PI18/00121 and PI21/00238) by Fondo Europeo de Desarrollo Regional (FEDER) “A way of Making Europe”. The project that gave rise to these results has received funding from “la Caixa” Foundation and the European Institute of Innovation and Technology, EIT (body of the European Union that receives support from the European Union’s Horizon 2020 research and innovation program), under the grant agreements LCF/TR/CI19/52460016 and LCF/TR/CC21/52490003. Additionally, this work was supported by the Consolidation of Competitive Research (IN607B2020/14) from GAIN from the Xunta de Galicia. M.Q. was supported by the Consolidation of Competitive Research (IN607B2020/14) from GAIN, Xunta de Galicia and A.R. was supported by a predoctoral contract (PRDLC21591RODR) from Fundación Científica AECC/AECC. Alfonsín has been supported by the Instituto de Salud Carlos III (ISCIII, Spain) under grant agreements (PI18/00121)es_ES
dc.description.sponsorshipXunta de Galicia; IN607B2020/14es_ES
dc.description.sponsorshipAsociación Española Contra el Cáncer. Fundación Científica AECC; PRDLC21591RODR
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI18%2F00121/ES/EFICACIA DE NUEVOS ANTITUMORALES DIRIGIDOS CONTRA EL CANCER DE COLON METASTASICO/
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI21%2F00238/ES/DEGRADATION DE PROTEINAS COMO DIANA TERAPEUTICA PARA SUPERAR LAS RESISTENCIA A TERAPIAS EN CANCER DE COLON/
dc.relation.urihttps://doi.org/10.3390/cancers14040990es_ES
dc.rightsAtribución 4.0 Internacionales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectE3 ubiquitin ligaseses_ES
dc.subjectCancer stem cellses_ES
dc.subjectPost-translational modificationes_ES
dc.subjectProtein degradationes_ES
dc.subjectUbiquitinationes_ES
dc.titleProtein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells [Review]es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleCancerses_ES
UDC.volume14es_ES
UDC.issue4es_ES
UDC.startPage990es_ES
dc.identifier.doi10.3390/cancers14040990


Ficheiros no ítem

Thumbnail
Nome:
license_rdf
Tamaño:
1.337Kb
Formato:
application/rdf+xml
Ver/abrir
Thumbnail
Nome:
Quiroga_Protein.pdf
Tamaño:
900.8Kb
Formato:
PDF
Ver/abrir

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem