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mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population
dc.contributor.author | Ramos-Louro, Paula | |
dc.contributor.author | Arellano Pérez Vertti, Rubén Daniel | |
dc.contributor.author | López Reyes, Alberto | |
dc.contributor.author | Martínez-Nava, Gabriela Angélica | |
dc.contributor.author | Espinosa, Rolando | |
dc.contributor.author | Pineda, Carlos | |
dc.contributor.author | González-Galarza, Faviel Francisco | |
dc.contributor.author | Argüello Astorga, Rafael | |
dc.contributor.author | Aguilar Muñiz, Lizette Sarai | |
dc.contributor.author | Hernández Terán, Fernando | |
dc.contributor.author | Parra Torres, Nancy Marbella | |
dc.contributor.author | Durán Sotuela, Alejandro | |
dc.contributor.author | Fernández-Moreno, Mercedes | |
dc.contributor.author | Balboa-Barreiro, Vanesa | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Rego-Pérez, Ignacio | |
dc.date.accessioned | 2022-04-18T08:02:26Z | |
dc.date.available | 2022-04-18T08:02:26Z | |
dc.date.issued | 2022-03-25 | |
dc.identifier.citation | Ramos-Louro P, Arellano Pérez Vertti RD, Reyes AL, Martínez-Nava GA, Espinosa R, Pineda C, González Galarza FF, Argüello Astorga R, Aguilar Muñiz LS, Hernández Terán F, Parra Torres NM, Durán Sotuela A, Fernández-Moreno M, Balboa Barreiro V, Blanco FJ, Rego-Pérez I. mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population. Sci Rep. 2022 Mar 25;12(1):5173. | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/2183/30473 | |
dc.description.abstract | [Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients (KL grade ≥ I) and (n = 364) healthy controls (KL grade = 0) from Mexico city and Torreon (Mexico). Both Caucasian and Amerindian mtDNA haplogroups were assigned by single base extension assay. A set of clinical and demographic variables, including obesity status, were considered to perform appropriate statistical approaches, including chi-square contingency tables, regression models and interaction analyses. To ensure the robustness of the predictive model, a statistical cross-validation strategy of B = 1000 iterations was used. All the analyses were performed using boot, GmAMisc and epiR package from R software v4.0.2 and SPSS software v24. The frequency distribution of the mtDNA haplogroups between OA patients and healthy controls for obese and non-obese groups showed the haplogroup A as significantly over-represented in knee OA patients within the obese group (OR 2.23; 95% CI 1.22-4.05; p-value = 0.008). The subsequent logistic regression analysis, including as covariate the interaction between obesity and mtDNA haplogroup A, supported the significant association of this interaction (OR 2.57; 95% CI 1.24-5.32; p-value = 0.011). The statistical cross-validation strategy confirmed the robustness of the regression model. The data presented here indicate a link between obesity in knee OA patients and mtDNA haplogroup A. | es_ES |
dc.description.sponsorship | This work is supported by Grants from Fondo de Investigación Sanitaria (PI17/00210, PI16/02124, PI20/00614, RETIC-RIER-RD16/0012/0002 and PRB3-ISCIII-PT17/0019/0014) integrated in the National Plan for Scientific Program, Development and Technological Innovation 2013–2016 and funded by the ISCIII-General Subdirection of Assessment and Promotion of Research-European Regional Development Fund (FEDER) “A way of making Europe” and Grant IN607A2017/11 from Xunta de Galicia. The authors further acknowledge AE CICA-INIBIC (ED431E 2018/03) for financial support. IRP is supported by Contrato Miguel Servet-II Fondo de Investigación Sanitaria (CPII17/00026) and AD-S is supported by Grant IN606A-2018/023 from Xunta de Galicia, Spain. The Biomedical Research Networking Center (CIBER) is an initiative from Instituto de Salud Carlos III (ISCIII) | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A2017/11 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431E 2018/03 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN606A-2018/023 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI17%2F00210/ES/Identificación de marcadores genéticos mitocondriales de progresión rápida de artrosis de rodilla mediante técnicas de secuenciación masiva / | |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI16%2F02124/ES/Determinación de índices predictivos de diagnóstico y pronóstico de artrosis de rodilla mediante la validación de biomarcadores proteicos/ | |
dc.relation | info:eu-repo/grantAgreement/MICINN/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00614/ES/Identificación de mutaciones de ADNmt específicas de artrosis mediante secuenciación masiva para valorar su impacto como futuras dianas terapéuticas y en el diganóstico de fenotipos/ | |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RD16%2F0012%2F0002/ES/Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER)/ | |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PT17%2F0019%2F0014/ES/ | |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CPII17%2F00026/ES/ | |
dc.relation.uri | https://doi.org/10.1038/s41598-022-09265-y | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Genetic markers | |
dc.subject | Genetics | |
dc.subject | Sequencing | |
dc.title | mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Scientific Reports | es_ES |
UDC.volume | 12 | es_ES |
UDC.issue | 1 | es_ES |
UDC.startPage | 5173 | es_ES |
dc.identifier.doi | 10.1038/s41598-022-09265-y |
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