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DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death
dc.contributor.author | Bonassi, Stefano | |
dc.contributor.author | Ceppi, Marcello | |
dc.contributor.author | Møller, Peter | |
dc.contributor.author | Azqueta, Amaya | |
dc.contributor.author | Milić, Mirta | |
dc.contributor.author | Neri, Monica | |
dc.contributor.author | Brunborg, Gunnar | |
dc.contributor.author | Godschalk, Roger | |
dc.contributor.author | Koppen, Gudrun | |
dc.contributor.author | Langie, Sabine | |
dc.contributor.author | Teixeira, João | |
dc.contributor.author | Bruzzone, Marco | |
dc.contributor.author | Da Silva, Juliana | |
dc.contributor.author | Benedetti, Danieli | |
dc.contributor.author | Cavallo, Delia | |
dc.contributor.author | Ursini, Cinzia Lucia | |
dc.contributor.author | Giovannelli, Lisa | |
dc.contributor.author | Moretti, Silvia | |
dc.contributor.author | Riso, Patrizia | |
dc.contributor.author | Del Bo’, Cristian | |
dc.contributor.author | Russo, Patrizia | |
dc.contributor.author | Dobrzyńska, Malgorzata | |
dc.contributor.author | Goroshinskaya, Irina A. | |
dc.contributor.author | Surikova, Ekaterina | |
dc.contributor.author | Staruchova, Marta | |
dc.contributor.author | Barančoková, Magdaléna | |
dc.contributor.author | Volkovova, Katarina | |
dc.contributor.author | Kažimírová, Alena | |
dc.contributor.author | Smolkova, Bozena | |
dc.contributor.author | Laffon, Blanca | |
dc.contributor.author | Valdiglesias, Vanessa | |
dc.contributor.author | Pastor, Susana | |
dc.contributor.author | Marcos, Ricard | |
dc.contributor.author | Hernández, Alba | |
dc.contributor.author | Gajski, Goran | |
dc.contributor.author | Spremo-Potparević, Biljana | |
dc.contributor.author | Živković, Lada | |
dc.contributor.author | Boutet-Robinet, Elisa | |
dc.contributor.author | Perdry, Hervé | |
dc.contributor.author | Lebailly, Pierre | |
dc.contributor.author | Pérez, Carlos L. | |
dc.contributor.author | Başaran, Nurşen | |
dc.contributor.author | Nemeth, Zsuzsanna | |
dc.contributor.author | Sáfár, Anna | |
dc.contributor.author | Dusinska, Maria | |
dc.contributor.author | Collins, Andrew | |
dc.date.accessioned | 2021-12-16T10:51:27Z | |
dc.date.available | 2021-12-16T10:51:27Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Bonassi, S., Ceppi, M., Møller, P. et al. DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Sci Rep 11, 16793 (2021). https://doi.org/10.1038/s41598-021-95976-7 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/29145 | |
dc.description | Author Correction: https://doi.org/10.1038/s41598-021-98620-6. The original version of this Article contained errors: The spelling of the author Monica Neri was incorrectly given as Neri Monica; Additionally, Affiliation 39 was incorrectly given as ‘National Institute of Health, Lisbon, Portugal’, the correct affiliation is listed below: National Institute of Health Doutor Ricardo Jorge, Porto, Portugal. The original Article has been corrected. | |
dc.description.abstract | [Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases. | es_ES |
dc.description.sponsorship | This article is based upon work from COST Action CA15132 (hCOMET), supported by COST (European Cooperation in Science and Technology). The work of SB and PR was supported by funds granted by the Italian Ministry of Health for Institutional Research (Ricerca Corrente) | es_ES |
dc.description.uri | https://doi.org/10.1038/s41598-021-98620-6 | |
dc.language.iso | eng | es_ES |
dc.relation.uri | https://doi.org/10.1038/s41598-021-95976-7 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Scientific Reports | es_ES |
UDC.volume | 11 | es_ES |
UDC.issue | 16793 | es_ES |
dc.identifier.doi | doi.org/10.1038/s41598-021-95976-7 |