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State-dependent geometry of population activity in rat auditory cortex
dc.contributor.author | Kobak, Dmitry | |
dc.contributor.author | Pardo-Vázquez, José L. | |
dc.contributor.author | Valente, Mafalda | |
dc.contributor.author | Machens, Christian K. | |
dc.contributor.author | Renart, Alfonso | |
dc.date.accessioned | 2021-12-01T08:35:16Z | |
dc.date.available | 2021-12-01T08:35:16Z | |
dc.date.issued | 2019-04-10 | |
dc.identifier.citation | Kobak D, Pardo-Vázquez JL, Valente M, Machens CK, Renart A. State-dependent geometry of population activity in rat auditory cortex. eLife. 2019;8:e44526 | es_ES |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | http://hdl.handle.net/2183/29024 | |
dc.description.abstract | [Abstract] The accuracy of the neural code depends on the relative embedding of signal and noise in the activity of neural populations. Despite a wealth of theoretical work on population codes, there are few empirical characterizations of the high-dimensional signal and noise subspaces. We studied the geometry of population codes in the rat auditory cortex across brain states along the activation-inactivation continuum, using sounds varying in difference and mean level across the ears. As the cortex becomes more activated, single-hemisphere populations go from preferring contralateral loud sounds to a symmetric preference across lateralizations and intensities, gain-modulation effectively disappears, and the signal and noise subspaces become approximately orthogonal to each other and to the direction corresponding to global activity modulations. Level-invariant decoding of sound lateralization also becomes possible in the active state. Our results provide an empirical foundation for the geometry and state-dependence of cortical population codes. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | eLife Sciences | es_ES |
dc.relation.uri | https://doi.org/10.7554/eLife.44526.001 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Acoustic stimulation | es_ES |
dc.subject | Auditory cortex | es_ES |
dc.subject | Auditory perception | es_ES |
dc.subject | Rats | es_ES |
dc.title | State-dependent geometry of population activity in rat auditory cortex | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | eLife | es_ES |
UDC.volume | 8 | es_ES |
UDC.startPage | e44526 | es_ES |
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