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Evaluation of Okadaic Acid-Induced Genotoxicity in Human Cells Using the Micronucleus Test and γH2AX Analysis
(Taylor and Francis, 2011-06-27)
[Abstract] Marine algal blooms have become a public health concern due to increasing frequency in the environment and severity of exposure consequences. Human intoxications produced by phycotoxins occur globally through ...
Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types
(Royal Society of Chemistry (Gran Bretaña), 2011-03-28)
[Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ...
Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type
(Elsevier, 2011-03-01)
[Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ...
Assessment of Okadaic Acid Effects on Cytotoxicity, DNA Damage and DNA Repair in Human Cells
(Elsevier, 2010-05-26)
[Abstract] Okadaic acid (OA) is a phycotoxin produced by several types of dinoflagellates causing diarrheic shellfish poisoning (DSP) in humans. Symptoms induced by DSP toxins are mainly gastrointestinal, but the intoxication ...
Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles
(Elsevier, 2013-03-26)
[Abstract] Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have ...
Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization
(Springer Nature, 2012-01-27)
[Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ...
The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells
(Elsevier, 2013-04-03)
[Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ...
Comparative Study on Effects of Two Different Types of Titanium Dioxide Nanoparticles on Human Neuronal Cells
(Elsevier, 2013-04-15)
[Abstract] Titanium dioxide (TiO2) are among most frequently used nanoparticles (NPs). They are present in a variety of consumer products, including food industry in which they are employed as an additive. The potential ...
Inter-Laboratory Variation in DNA Damage Using a Standard Comet Assay Protocol
(Oxford University Press, 2012-07-27)
[Abstract] There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would ...
Endocrine and Immunological Parameters in Individuals Involved in Prestige Spill Cleanup Tasks Seven Years After the Exposure
(Elsevier, 2013-06-20)
[Abstract] In November 2002 the oil tanker Prestige spilled 63,000tonnes of heavy oil off the northwest coast of Spain, impacting more than 1000km of coastline. A general concern led to a huge mobilization of human and ...