Listar Grupo de Investigación en Nanotoxicoloxía e Toxicoloxía Xenética (NANOTOXGEN) por fecha de publicación

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    • Genetic Polymorphism in Cytochrome P450 1B1 in a Spanish Population [Short Communication] 

      Pérez-Cadahía, Beatriz; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Wiley, 2007-06-02)

    • Cytogenetic Effects Induced by Prestige Oil on Human Populations: The Role of Polymorphisms in Genes Involved in Metabolism and DNA Repair 

      Pérez-Cadahía, Beatriz; Laffon, Blanca; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina (Elsevier, 2008-04-18)
      [Abstract] The spill from the oil tanker Prestige (NW Spain, November 2002) was perhaps the biggest ecological disaster that happened worldwide in the last decades. As a consequence of this catastrophe a general concern ...

    • The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes 

      Laffon, Blanca; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina (Springer, 2009-05-08)
      [Abstract] The objective of this work was to evaluate the effects of selenomethionine (SeMet) on the induction, repair, and persistence of DNA damage in human leukocytes challenged with bleomycin (BLM). Comet assay was ...

    • Assessment of Okadaic Acid Effects on Cytotoxicity, DNA Damage and DNA Repair in Human Cells 

      Valdiglesias, Vanessa; Méndez, Josefina; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Laffon, Blanca (Elsevier, 2010-05-26)
      [Abstract] Okadaic acid (OA) is a phycotoxin produced by several types of dinoflagellates causing diarrheic shellfish poisoning (DSP) in humans. Symptoms induced by DSP toxins are mainly gastrointestinal, but the intoxication ...

    • Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Méndez, Josefina (Elsevier, 2011-03-01)
      [Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ...

    • Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Royal Society of Chemistry (Gran Bretaña), 2011-03-28)
      [Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ...

    • Evaluation of Okadaic Acid-Induced Genotoxicity in Human Cells Using the Micronucleus Test and γH2AX Analysis 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Taylor and Francis, 2011-06-27)
      [Abstract] Marine algal blooms have become a public health concern due to increasing frequency in the environment and severity of exposure consequences. Human intoxications produced by phycotoxins occur globally through ...

    • Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)
      [Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ...

    • Inter-Laboratory Variation in DNA Damage Using a Standard Comet Assay Protocol 

      Forchhammer, Lykke; Ersson, Clara; Loft, Steffen; Möller, Lennart; Godschalk, Roger W. L.; Schooten, Frederik J. van; Jones, George D. D.; Higgins, Jennifer A.; Cooke, Marcus; Mistry, Vilas; Karbaschi, Mahsa; Collins, Andrew R.; Azqueta, Amaya; Phillips, David H.; Sozeri, Osman; Routledge, Michael N.; Nelson-Smith, Kirsty; Riso, Patrizia; Porrini, Marisa; Matullo, Giuseppe; Allione, Alessandra; Stępnik, Maciej; Komorowska, Magdalena; Teixeira, João Paulo; Costa, Solange; Corcuera, Laura-Ana; López de Cerain, Adela; Laffon, Blanca; Valdiglesias, Vanessa; Møller, Peter (Oxford University Press, 2012-07-27)
      [Abstract] There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would ...

    • γH2AX as a Marker of DNA Double Strand Breaks and Genomic Instability in Human Population Studies [Review] 

      Valdiglesias, Vanessa; Giunta, Simona; Fenech, M.; Neri, Monica; Bonassi, Stefano (Elsevier, 2013-02-13)
      [Abstract] DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells. Failure to detect DSB and activate appropriate DNA damage responses can cause genomic instability, leading to tumorigenesis ...

    • Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles 

      Valdiglesias, Vanessa; Costa, C.; Kiliç, Gözde; Costa, Solange; Pásaro, Eduardo; Laffon, Blanca; Teixeira, João Paulo (Elsevier, 2013-03-26)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have ...

    • The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Méndez, Josefina; Pásaro, Eduardo; Laffon, Blanca (Elsevier, 2013-04-03)
      [Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ...

    • Comparative Study on Effects of Two Different Types of Titanium Dioxide Nanoparticles on Human Neuronal Cells 

      Valdiglesias, Vanessa; Costa, C.; Sharma, Vyom; Kiliç, Gözde; Pásaro, Eduardo; Teixeira, João Paulo; Dhawan, Alok; Laffon, Blanca (Elsevier, 2013-04-15)
      [Abstract] Titanium dioxide (TiO2) are among most frequently used nanoparticles (NPs). They are present in a variety of consumer products, including food industry in which they are employed as an additive. The potential ...

    • Endocrine and Immunological Parameters in Individuals Involved in Prestige Spill Cleanup Tasks Seven Years After the Exposure 

      Laffon, Blanca; Aguilera, Francisco; Ríos-Vázquez, Julia; García Lestón, Julia; Fuchs, Dietmar; Valdiglesias, Vanessa; Pásaro, Eduardo (Elsevier, 2013-06-20)
      [Abstract] In November 2002 the oil tanker Prestige spilled 63,000tonnes of heavy oil off the northwest coast of Spain, impacting more than 1000km of coastline. A general concern led to a huge mobilization of human and ...

    • Sequence characterization of the 5S ribosomal DNA and the internal transcribed spacer (ITS) region in four European Donax species (Bivalvia: Donacidae) 

      Méndez, Josefina; Nantón, Ana; Fernández-Pérez, Jenyfer (BioMed Central, 2018)
      [Abstract] Background: The whole repeat unit of 5S rDNA and the internal transcribed spacer (ITS) of four European Donax species were analysed. After amplifying, cloning and sequencing several 5S and ITS units, their basic ...

    • Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents 

      Avecilla, Fernando; Tariq, Saba; Mondal, Neelima; Azam, Amir; Sharma, Guru Prasad (Elsevier, 2018)
      [Abstract] In an effort to develop novel antiamoebic scaffolds having better efficacy than the standard drug metronidazole (IC50 = 1.80 μM) used against Entamoeba histolytica, quinazolin-4(3H)-one Schiff base conjugates ...

    • Vitamin D and Its Synthetic Analogs 

      Maestro, Miguel; Molnár, Ferdinand; Carlberg, Carsten (ACS Publications, 2019)
      [Abstract] For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also ...

    • The hCOMET Project: International Database Comparison of Results with the Comet Assay in Human Biomonitoring. Baseline Frequency of DNA Damage and Effect of Main Confounders 

      Milić, Mirta; Ceppi, Marcello; Bruzzone, Marco; Azqueta, Amaya; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine; Møller, Peter; Alija, Avdulla; Anderson, Diana; Andreoli, Cristina; Asllani, Fisnik; Boutet-Robinet, Elisa; Buschini, Annamaria; Cavallo, Delia; Costa, Solange; Da Silva, Juliana; Del Boˊ, Cristian; Djelić, Ninoslav; Dobrzyńska, Malgorzata; Dvořáková, Monika; Gajski, Goran; Galati, Serena; García Lima, Omar; Giovannelli, Lisa; Goroshinskaya, Irina A.; Grindel, Annemarie; Hernández, Alba; Hernández, Carlos; Holven, Kirsten B.; Ibero-Baraibar, Idoia; Ottestad, Inger; Kadioglu, Ela; Kuznetsova, Elena; Ladeira, Carina; Laffon, Blanca; Lamonaca, Palma; Lebailly, Pierre; Louro, Henriqueta; Mandina Cardoso, Tania; Marcon, Francesca; Marcos, Ricard; Moretti, Massimo; Moretti, Silvia; Najafzadeh, Mojgan; Nemeth, Zsuzsanna; Neri, Monica; Novotna, Bozena; Orlow, Irene; Paduchova, Zuzana; Pastor, Susana; Perdry, Hervé; Spremo-Potparević, Biljana; Ramadhani, Dwi; Riso, Patrizia; Rohr, Paula; Rojas, Emilio; Rossner, Pavel; Sardas, Semra; Silva, Maria João; Sirota, Nikolay; Smolkova, Bozena; Staruchova, Marta; Stetina, Rudolf; Stopper, Helga; Ursini, Cinzia Lucia; Valdiglesias, Vanessa; Valverde, Mahara; Volkovova, Katarina; Wagner, Karl-Heinz; Živković, Lada; Dušinská, Maria; Collins, Andrew R.; Bonassi, Stefano; Teixeira, João; Andrade, Vanessa Moraes de; Bankoglu, Ezgi Eylül; Barančoková, Magdaléna; Pereira, Cristiana; Dimitrijević-Srećković, Vesna; Sáfár, Anna; Surikova, Ekaterina; Vodička, Pavel; Başaran, Nurşen; Costa, C.; Ďuračková, Zdeňka; Kažimírová, Alena; Gützkow, Kristine Bjerve; Ulven, Stine Marie (2021)
      [Abstract] The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification ...

    • DNA Damage in Circulating Leukocytes Measured With the Comet Assay May Predict the Risk of Death 

      Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Neri, Monica; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine; Teixeira, João; Bruzzone, Marco; Da Silva, Juliana; Benedetti, Danieli; Cavallo, Delia; Ursini, Cinzia Lucia; Giovannelli, Lisa; Moretti, Silvia; Riso, Patrizia; Del Bo’, Cristian; Russo, Patrizia; Dobrzyńska, Malgorzata; Goroshinskaya, Irina A.; Surikova, Ekaterina; Staruchova, Marta; Barančoková, Magdaléna; Volkovova, Katarina; Kažimírová, Alena; Smolkova, Bozena; Laffon, Blanca; Valdiglesias, Vanessa; Pastor, Susana; Marcos, Ricard; Hernández, Alba; Gajski, Goran; Spremo-Potparević, Biljana; Živković, Lada; Boutet-Robinet, Elisa; Perdry, Hervé; Lebailly, Pierre; Pérez, Carlos L.; Başaran, Nurşen; Nemeth, Zsuzsanna; Sáfár, Anna; Dusinska, Maria; Collins, Andrew (2021)
      [Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, ...

    • Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO2 Nanoparticles on SH-SY5Y Cells 

      Fernández-Bertólez, Natalia; Brandão, Fátima; Costa, C.; Pásaro, Eduardo; Teixeira, João; Laffon, Blanca; Valdiglesias, Vanessa (2021)
      [Abstract] Standard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) ...