Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
Use this link to cite
http://hdl.handle.net/2183/28451
Except where otherwise noted, this item's license is described as Attribución 4.0 Internacional (CC BY 4.0)
Collections
- GI-MODES - Artigos [143]
Metadata
Show full item recordTitle
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and LeiomyosarcomaAuthor(s)
Date
2021Citation
Sanegre S, Eritja N, de Andrea C, Diaz-Martin J, Diaz-Lagares Á, Jácome MA, Salguero-Aranda C, García Ros D, Davidson B, Lopez R, Melero I, Navarro S, Ramon y Cajal S, de Alava E, Matias-Guiu X and Noguera R (2021) Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma. Front. Cell Dev. Biol. 9:670185. doi: 10.3389/fcell.2021.670185
Abstract
[Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.
Keywords
Tumor-host interface
Tumor microenvironment
Extracellular matrix
Reticular fibers
Immune cells
Gene expression
Epigenetic profiles
Tumor microenvironment
Extracellular matrix
Reticular fibers
Immune cells
Gene expression
Epigenetic profiles
Editor version
Rights
Attribución 4.0 Internacional (CC BY 4.0)