Skip navigation
  •  Inicio
  • UDC 
    • Cómo depositar
    • Políticas do RUC
    • FAQ
    • Dereitos de Autor
    • Máis información en INFOguías UDC
  • Percorrer 
    • Comunidades
    • Buscar por:
    • Data de publicación
    • Autor
    • Título
    • Materia
  • Axuda
    • español
    • Gallegan
    • English
  • Acceder
  •  Galego 
    • Español
    • Galego
    • English
  
Ver ítem 
  •   RUC
  • Facultade de Ciencias
  • Investigación (FCIE)
  • Ver ítem
  •   RUC
  • Facultade de Ciencias
  • Investigación (FCIE)
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

Expanding the Ligand Classes Used for Mn(II) Complexation: Oxa-aza Macrocycles Make the Difference

Thumbnail
Ver/abrir
Esteban_Gomez_David_2021_Expanding_Ligand_Classes_Mn(II)_Complexation_Oxa-aza_Macrocycles_Make_Difference.pdf (13.98Mb)
Use este enlace para citar
http://hdl.handle.net/2183/27664
Attribution 4.0 International
A non ser que se indique outra cousa, a licenza do ítem descríbese como Attribution 4.0 International
Coleccións
  • Investigación (FCIE) [1228]
Metadatos
Mostrar o rexistro completo do ítem
Título
Expanding the Ligand Classes Used for Mn(II) Complexation: Oxa-aza Macrocycles Make the Difference
Autor(es)
Kálmán, Ferenc
Nagy, Viktória
Uzal-Varela, Rocío
Pérez-Lourido, Paulo
Esteban-Gómez, David
Garda, Zoltán
Pota, Kristof
Mezei, Roland
Pallier, Agnès
Tóth, Éva
Platas-Iglesias, Carlos
Tircsó, Gyula
Data
2021-03-10
Cita bibliográfica
Kálmán, F.K.; Nagy, V.; Uzal-Varela, R.; Pérez-Lourido, P.; Esteban-Gómez, D.; Garda, Z.; Pota, K.; Mezei, R.; Pallier, A.; Tóth, É.; Platas-Iglesias, C.; Tircsó, G. Expanding the Ligand Classes Used for Mn(II) Complexation: Oxa-aza Macrocycles Make the Difference. Molecules 2021, 26, 1524. https://doi.org/10.3390/molecules26061524
Resumo
[Abstract] We report two macrocyclic ligands based on a 1,7-diaza-12-crown-4 platform functionalized with acetate (𝑡O2DO2A²⁻) or piperidineacetamide (𝑡O2DO2AMᴾⁱᵖ) pendant arms and a detailed characterization of the correspondingMn(II) complexes. The X-ray structure of [Mn(𝑡O2DO2A)(H₂O)]∙.2H₂O shows that the metal ion is coordinated by six donor atoms of the macrocyclic ligand and one water molecule, to result in seven-coordination. The Cu(II) analogue presents a distorted octahedral coordination environment. The protonation constants of the ligands and the stability constants of the complexes formed with Mn(II) and other biologically relevant metal ions (Mg(II), Ca(II), Cu(II) and Zn(II)) were determined using potentiometric titrations (∕ = 0.15 M NaCl, T = 25 ºC). The conditional stabilities of Mn(II) complexes at pH 7.4 are comparable to those reported for the cyclen-based 𝑡DO2A²⁻ ligand. The dissociation of the Mn(II) chelates were investigated by evaluating the rate constants of metal exchange reactions with Cu(II) under acidic conditions (∕ = 0.15MNaCl, T = 25 ºC). Dissociation of the [Mn(𝑡O2DO2A)(H₂O)] complex occurs through both proton- and metal-assisted pathways, while the [Mn(𝑡O2DO2AMᴾⁱᵖ)(H₂O)] analogue dissociates through spontaneous and proton-assisted mechanisms. The Mn(II) complex of 𝑡O2DO2A²⁻ is remarkably inert with respect to its dissociation, while the amide analogue is significantly more labile. The presence of a water molecule coordinated to Mn(II) imparts relatively high relaxivities to the complexes. The parameters determining this key property were investigated using ¹⁷O NMR (Nuclear Magnetic Resonance) transverse relaxation rates and ¹H nuclear magnetic relaxation dispersion (NMRD) profiles.
Palabras chave
Manganese
Magnetic resonance imaging
Stability
Dissociation kinetics
Water exchange
Contrast agents
Macrocycles
 
Versión do editor
https://doi.org/10.3390/molecules26061524
Dereitos
Attribution 4.0 International
ISSN
1420-3049

Listar

Todo RUCComunidades e colecciónsPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulaciónEsta colecciónPor data de publicaciónAutoresTítulosMateriasGrupo de InvestigaciónTitulación

A miña conta

AccederRexistro

Estatísticas

Ver Estatísticas de uso
Sherpa
OpenArchives
OAIster
Scholar Google
UNIVERSIDADE DA CORUÑA. Servizo de Biblioteca.    DSpace Software Copyright © 2002-2013 Duraspace - Suxestións