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Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis
dc.contributor.author | Vaamonde-García, Carlos | |
dc.contributor.author | Flórez-Fernández, Noelia | |
dc.contributor.author | Torres Pérez, María Dolores | |
dc.contributor.author | Lamas Vázquez, María José | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Domínguez, Herminia | |
dc.contributor.author | Meijide-Faílde, Rosa | |
dc.date.accessioned | 2021-03-05T10:55:53Z | |
dc.date.issued | 2021-01-26 | |
dc.identifier.citation | Vaamonde-García C, Flórez-Fernández N, Torres MD, Lamas-Vázquez MJ, Blanco FJ, Domínguez H, Meijide-Faílde R. Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis. Carbohydr Polym. 2021 Apr 15;258:117692. | es_ES |
dc.identifier.issn | 0144-8617 | |
dc.identifier.uri | http://hdl.handle.net/2183/27425 | |
dc.description.abstract | [Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules in OA treatment. However, the variability between fucoidans makes difficult the pursuit of the most suitable candidate to target specific pathological processes. By an in vitro experimental approach in chondrocytes and fibroblast-like synoviocytes, we observed that chemical composition of fucoidan, and specifically the phlorotannin content and the ratio sulfate:fucose, seems critically relevant for its biological activity. Nonetheless, other factors like concentration and molecular weight of the fucoidan may influence on its beneficial effects. Additionally, a cell-type dependent response was also detected. Thus, our results shed light on the potential use of fucoidans as natural molecules in the treatment of key pathological processes in the joint that favor the development of rheumatic disorders as OA. | es_ES |
dc.description.sponsorship | Financial support from the Xunta de Galicia(Centro singular de investigación de Galicia accreditation 2019–2022) and the European Union (European Regional Development Fund - ERDF), is grate fully acknowledged [grant number ED431G2019/06]. N.F.-F. thanks Xunta de Galicia for her postdoctoral contract [grant number ED481B 2018/071]. M.D.T. thanks Spanish Ministry of Economy and Competitivenessfor her postdoctoral grant [grant number RYC2018-024454-I]. C.V.-G. thanks Xunta de Galicia for his postdoctoral contract [grant number ED481D 2017/023]. | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G2019/06 | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | https://doi.org/10.1016/j.carbpol.2021.117692 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 4.0 (CC-BY-NC-ND 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fucus vesiculosus fucoidan | es_ES |
dc.subject | Macrocystis pyrifera fucoidan | es_ES |
dc.subject | Undaria pinnatifida fucoidan | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.subject | Osteoarthritic chondrocytes | es_ES |
dc.subject | Synovial fibroblasts | es_ES |
dc.title | Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.date.embargoEndDate | 2022-01-26 | es_ES |
dc.date.embargoLift | 2022-01-26 | |
UDC.journalTitle | Carbohydrate Polymers | es_ES |
UDC.volume | 258 | es_ES |
UDC.startPage | 117692 | es_ES |
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