Scaffold-Mediated Gene Delivery for Osteochondral Repair
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Scaffold-Mediated Gene Delivery for Osteochondral RepairAuthor(s)
Date
2020-09-29Citation
Madry, H.; Venkatesan, J.K.; Carballo-Pedrares, N.; Rey-Rico, A.; Cucchiarini, M. Scaffold-Mediated Gene Delivery for Osteochondral Repair. Pharmaceutics 2020, 12, 930. https://doi.org/10.3390/pharmaceutics12100930
Abstract
[Abstract]
Osteochondral defects involve both the articular cartilage and the underlying subchondral
bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene
vectors has recently emerged as an attractive therapeutic concept for osteochondral repair. The goal
of this review is to provide an overview of the variety of biomaterials employed as nonviral or viral
gene carriers for osteochondral repair approaches both in vitro and in vivo, including hydrogels,
solid scaffolds, and hybrid materials. The data show that a site-specific delivery of therapeutic gene
vectors in the context of acellular or cellular strategies allows for a spatial and temporal control of
osteochondral neotissue composition in vitro. In vivo, implantation of acellular hydrogels loaded
with nonviral or viral vectors has been reported to significantly improve osteochondral repair in
translational defect models. These advances support the concept of scaffold-mediated gene delivery
for osteochondral repair.
Keywords
Osteochondral repair
Gene therapy
Tissue engineering
Controlled delivery
Gene therapy
Tissue engineering
Controlled delivery
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Rights
Atribución 4.0 Internacional (CC BY 4.0)
ISSN
1999-4923