Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases

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Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseasesAuthor(s)
Date
2020-08-25Citation
Sanjurjo-Rodríguez C, Castro-Viñuelas R, Piñeiro-Ramil M, Rodríguez-Fernández S, Fuentes-Boquete I, Blanco FJ, Díaz-Prado S. Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases. Int J Mol Sci. 2020 Aug 25;21(17):6124.
Abstract
[Abstract]
Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells
capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable
use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders
a ecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal
diseases are one of the major causes of disability worldwide and impose an important socio-economic
burden. To date there is neither cure nor proven approach for e ectively treating most of these
conditions and therefore new strategies involving the use of cells have been increasingly investigated
in the recent years. Nevertheless, some limitations related to the safety and di erentiation protocols
among others remain, which humpers the translational application of these strategies. Nonetheless,
the potential is indisputable and iPSCs are likely to be a source of di erent types of cells useful in the
musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to
illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration
preclinical studies that have been carried out in the musculoskeletal field by using iPSCs.
Keywords
iPSCs
Pluripotency
Regenerative medicine
EVs
Bone
Cartilage
Muscle
Intervertebral disc
Pluripotency
Regenerative medicine
EVs
Bone
Cartilage
Muscle
Intervertebral disc
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Creative Commons Attribution 4.0 International Licence (CC-BY 4.0)
ISSN
1422-0067