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Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
dc.contributor.author | Carballo-Pedrares, Natalia | |
dc.contributor.author | Fuentes Boquete, Isaac Manuel | |
dc.contributor.author | Díaz-Prado, Silvia | |
dc.contributor.author | Rey-Rico, Ana | |
dc.date.accessioned | 2020-09-29T08:15:16Z | |
dc.date.available | 2020-09-29T08:15:16Z | |
dc.date.issued | 2020-08-10 | |
dc.identifier.citation | Carballo-Pedrares N, Fuentes-Boquete I, Díaz-Prado S, Rey-Rico A. Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview. Pharmaceutics. 2020;12:752. | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/2183/26254 | |
dc.description.abstract | [Abstract] Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099389-A-I00/ES/CRIOGELES ACTIVADOS POR GENES PARA REPARACION DE CARTILAG | |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.uri | https://doi.org/10.3390/pharmaceutics12080752 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International Licence (CC-BY 4.0) | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Musculoskeletal tissue | es_ES |
dc.subject | Cardiovascular tissue | es_ES |
dc.subject | Wound healing | es_ES |
dc.subject | Nervous tissue | es_ES |
dc.subject | Gene therapy | es_ES |
dc.subject | Controlled delivery | es_ES |
dc.subject | Hydrogels | es_ES |
dc.subject | Nonviral vectors | es_ES |
dc.title | Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Pharmaceutics | es_ES |
UDC.volume | 12 | es_ES |
UDC.issue | 8 | es_ES |
UDC.startPage | 752 | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics12080752 |
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