ListarGrupo de Investigación en Reumatoloxía e Saúde (GIR-S) por tema "Inflammation"

Mostrando ítems 1-7 de 7

    • A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis 

      Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)
      [Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ...

    • Anti-inflammatory potential of ulvan 

      Flórez-Fernández, Noelia; Rodríguez-Coello, Arianna; Latire, Thomas; Bourgougnon, Natalie; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Muíños, Antonio; Meijide-Faílde, Rosa; Blanco García, Francico J; Vaamonde-García, Carlos; Domínguez, Herminia (Elsevier, 2023-12-31)
      [Abstract] Green seaweeds are a widespread group of marine macroalgae that could be regarded as biorenewable source of valuable compounds, in particular sulfated polysaccharides like ulvans with interesting biological ...

    • Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
      [Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...

    • Histone extraction from human articular cartilage for the study of epigenetic regulation in osteoarthritis 

      Núñez-Carro, Carmen; Blanco-Blanco, Margarita; Montoya, Tatiana; Villagrán-Andrade, Karla M.; Hermida-Gómez, Tamara; Blanco García, Francisco J; De Andrés, María C. (MDPI, 2022-03-20)
      [Abstract] Osteoarthritis (OA) is a chronic disease that affects articular cartilage, causing its degeneration. Although OA is one of the most prevalent pathologies globally, there are no definitive treatments available. ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis 

      López-Armada, María José; Fernández-Rodríguez, Jennifer Adriana; Blanco García, Francisco J (MDPI, 2022-06-12)
      [Abstract] Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an ...

    • Relevance of the extraction stage on the anti-inflammatory action of fucoidans 

      Flórez-Fernández, Noelia; Vaamonde-García, Carlos; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Lamas-Vázquez, María J.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2023-03-01)
      [Abstract] The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining ...