• A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype 

      Quelle Regaldie, Ana; Folgueira, Mónica; Yáñez, Julián; Sobrido Cameán, Daniel; Alba-González, Anabel; Barreiro-Iglesias, Antón; Sobrido, María-Jesús; Sánchez Piñón, Laura (MDPI, 2022)
      [Abstract] NOP56 belongs to a C/D box small nucleolar ribonucleoprotein complex that is in charge of cleavage and modification of precursor ribosomal RNAs and assembly of the 60S ribosomal subunit. An intronic expansion ...
    • Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit 

      Pérez-Rius, Carla; Folgueira, Mónica; Elorza-Vidal, Xabier; Alia, A.; Hoegg-Beiler, Maja B.; Eeza, Muhamed N. H.; Díaz, María Luz; Nunes, Virginia; Barrallo-Gimeno, Alejandro; Estévez, Raúl (BMC, 2019-11-21)
      [Abstract] Background: Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a rare type of leukodystrophy characterized by astrocyte and myelin vacuolization, epilepsy and early-onset macrocephaly. MLC is ...
    • Distribution of Neurogranin-Like Immunoreactivity in the Brain and Sensory Organs of the Adult Zebrafish 

      Alba-González, Anabel; Folgueira, Mónica; Castro, Antonio; Anadón, Ramón; Yáñez, Julián (Wiley, 2022-01-11)
      [Abstract] We studied the expression of neurogranin in the brain and some sensory organs (barbel taste buds, olfactory organs, and retina) of adult zebrafish. Database analysis shows zebrafish has two paralog neurogranin ...
    • Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos 

      Valdiglesias, Vanessa; Alba-González, Anabel; Fernández-Bertólez, Natalia; Touzani, Assia; Ramos-Pan, Lucía; Reis, Ana Teresa; Moreda-Piñeiro, Jorge; Yáñez, Julián; Laffon, Blanca; Folgueira, Mónica (MDPI, 2023-08-01)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are among the most widely used nanomaterials. They have multiple applications in cosmetics, textiles, paints, electronics and, recently, also in biomedicine. This extensive use ...
    • Severe Neurometabolic Phenotype in NPC1−/− Zebrafish With a C-Terminal Mutation 

      Quelle Regaldie, Ana; Gandoy-Fieiras, Nerea; Villamayor, Paula R.; Maceiras, Sandra; Losada, Ana; Folgueira, Mónica; Cabezas Sáinz, Pablo; Barreiro-Iglesias, Antón; Villar López, María; Quiroga-Berdeal, María Isabel; Sánchez, Laura; Sobrido, María Jesús (Frontiers, 2023-03-17)
      [Abstract] Niemann Pick disease type C (NPC) is an autosomal recessive neurodegenerative lysosomal disorder characterized by an accumulation of lipids in different organs. Clinical manifestations can start at any age and ...