Nitric oxide-mediated cortical activation: a diffuse wake-up system
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Nitric oxide-mediated cortical activation: a diffuse wake-up systemDate
2003Citation
Mariño J, Cudeiro J. Nitric oxide-mediated cortical activation: a diffuse wake-up system. J Neurosci. 2003;23(10):4299-4307.
Abstract
Nitric oxide (NO) has been implicated in some of the central pathways engaged in the regulation of the sleep–wake cycle. The existence of
nitric oxide synthase (NOS) in the cholinergic basal forebrain (BF) cells projecting to the cortex suggests a role for NO in the activation
induced by the BF during arousal. We tested, in the anesthetized cat, the hypothesis that inhibition of NOS would decrease the ability of
BFcholinergic fibers to induce cortical activation. In control conditions,BFstimulation evoked an awake-likeEEGpattern (i.e., a decrease
in the low-frequency– high-amplitude oscillatory activity and an increase in the high-frequency–low-amplitude activity). After blocking
NOS activity, the capacity of BF stimulation to induce cortical activation was strongly impaired. Furthermore, voltammetric measurements
of NO levels revealed an increase in cortical NO after BF stimulation, also blocked by systemic NOS inhibition. These results
indicate that the blockade of NOS activity significantly reduces the ability of BF stimulation to induce changes in the EEG pattern and
suggest a role for NO in the BF–cholinergic system implicated in arousal mechanisms.
Keywords
Basal forebrain
Sleep-wake cycle
V1
ACh
Nitro-arginine
Nitroindazole
Sleep-wake cycle
V1
ACh
Nitro-arginine
Nitroindazole
ISSN
0306-4522