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Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis
(Elsevier, 2018-07-20)
[Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ...
Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis
(Elsevier, 2018-05-29)
Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis
(PLoS, 2018-05-07)
[Abstract] Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. ...
La artrosis y la ateroesclerosis de la articulación
(Elsevier, 2018-09-08)
What did we learn from 'omics' studies in osteoarthritis
(Wolters Kluwer, 2018-01-01)
[Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for ...
Clinical, Patient-Reported, and Ultrasound Outcomes from an Open-Label, 12-week Observational Study of Certolizumab Pegol in Spanish Patients with Rheumatoid Arthritis with or without Prior Anti-TNF Exposure
(Elsevier, 2018-09-17)
[Abstract] Objectives: To assess the effectiveness and safety of certolizumab pegol (CZP) in Spanish patients with RA.
Materials and methods: SONAR (NCT01526434), a 12-week, open-label, prospective, observational, ...
In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis
(Elsevier, 2018-08-25)
[Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
(BMC, 2018-12-20)
[Abstract] Background. In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The ...
Intraneural IFG-1 in cryopreserved nerve isografts increase neural regeneration and functional recovery in the rat sciatic nerve
(Oxford, 2018-07-27)
[Abstract] Background: Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation.
Objective: To evaulate the effect of ...
Cell therapy and tissue engineering for cartilage repair
(IntechOpen, 2018-02-14)
[Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial
joint. The self-repair capacity of this tissue is very limited and, currently, there
is no effective treatment ...