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Mostrando ítems 11-20 de 21
Mitochondrial Respiratory Chain Dysfunction Modulates Metalloproteases -1, -3 and -13 in Human Normal Chondrocytes in Culture
(BioMed Central, 2013-08-09)
[Abstract] Background. Mitochondrion has an important role in the osteoarthritis (OA) pathology. We have previously demonstrated that the alteration of the mitochondrial respiratory chain (MRC) contributes to the inflammatory ...
Optical Biomarkers for the Diagnosis of Osteoarthritis through Raman Spectroscopy: Radiological and Biochemical Validation Using Ex Vivo Human Cartilage Samples
(MDPI, 2021-03-18)
[Abstract]
Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. Raman spectroscopy (RS) has been recently proposed as a label-free tool to detect molecular ...
Descripción de la cohorte PROCOAC (PROspective COhort of A Coruña): cohorte prospectiva española para el estudio de la osteoartritis
(Elsevier, 2020-11-13)
[Resumen] Introducción y objetivo. El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte ...
Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
(Elsevier, 2023-03-08)
[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.
Design: An autophagy-related ...
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
(BMJ, 2023-03-17)
[Abstract] Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
(BioMed Central, 2023-03-30)
[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...
Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts
(Nature Research, 2020-03-06)
[Abstract]
Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
(BioMed Central, 2012-08-12)
[Abstract]
Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...