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Cell therapy and tissue engineering for cartilage repair
(IntechOpen, 2018-02-14)
[Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial
joint. The self-repair capacity of this tissue is very limited and, currently, there
is no effective treatment ...
Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage
(Bentham Open, 2012-04-06)
[Abstract]
Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies.
Materials and Methodology: The study ...
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
(Elsevier, 2017-11-01)
[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...
Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells
(Ivyspring, 2017-09-28)
[Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds.
Lesions were made ...
Human amniotic mesenchymal stromal cells as favorable source for cartilage repair
(Mary Ann Liebert, 2017-01-10)
[Abstract]
Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...
Induced pluripotent stem cells for cartilage repair: current status and future perspectives
(AO Research Institute Davos, 2018-09-11)
[Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...
Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features
(Hindawi, 2020-06-16)
[Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...
Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases
(MDPI, 2020-08-25)
[Abstract]
Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells
capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable
use of iPSCs ...
Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts
(Nature Research, 2020-03-06)
[Abstract]
Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...
Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases
(Elsevier, 2020-03)
[Abstract]
Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...