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Mostrando ítems 11-20 de 74
Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12
(Wiley, 2019-03-22)
[Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
(Elsevier, 2006-05-05)
[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...
PROCOAC (PROspective COhort of A Coruña) description: Spanish prospective cohort to study osteoarthritis
(Elsevier, 2021-05-03)
[Abstract] Introduction and objective: The use of well characterized osteoarthritis (OA) cohorts is mandatory for the study and knowledge of this disease. Currently, there is no prospective cohort in this pathology in ...
Impact of prevalence ratios of chondroitin sulfate (CS)- 4 and -6 isomers derived from marine sources in cell proliferation and chondrogenic differentiation processes
(MDPI, 2020-01-31)
[Abstract]
Osteoarthritis is the most prevalent rheumatic disease. During disease progression,
differences have been described in the prevalence of chondroitin sulfate (CS) isomers. Marine
derived-CS present a higher ...
Leukocyte telomere length in patients with radiographic knee osteoarthritis
(Wiley, 2019-11-29)
[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...
CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: an Animal Model
(PLoS, 2017-11-30)
[Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ...
Is It Time for Epigenetics in Osteoarthritis?
(Wiley, 2014-05-16)
[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...
Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
(Wiley, 2010-07-21)
[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers. Subpopulations of human ...
A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine
(Nature, 2014-06-10)
[Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)
[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...