ListarINIBIC- REUMA - Artigos por tema "Senescence"

Mostrando ítems 1-3 de 3

    • Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy 

      Nogueira Recalde, Uxía; Lorenzo Gómez, Irene; Blanco García, Francisco J; Loza, María Isabel; Grassi, Diego; Shirinsky, Valery; Shirinsky, Ivan; Lotz, Martin; Robbins, Paul D.; Domínguez, Eduardo; Caramés, Beatriz (Elsevier, 2019-07-05)
      [Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was ...

    • Generation of mesenchymal cell lines derived from aged donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

    • mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model 

      Scotece, Morena; Vaamonde-García, Carlos; Lechuga-Vieco, Ana Victoria; Centeno Cortés, Alberto; Jiménez Gómez, María Concepción; Filgueira-Fernández, Purificación; Rego-Pérez, Ignacio; Enríquez, José Antonio; Blanco García, Francisco J (Impact Journals, 2022-07-02)
      [Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ...