Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 178-182 de 182

    • Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis 

      López-Rodríguez, Rosario; Pérez-Pampin, Eva; Márquez, Ana; Blanco García, Francisco J; Joven, Beatriz; Carreira, Patricia; Ferrer, Miguel Ángel; Cáliz, Rafael; Valor, Lara; Narváez, Javier; Cañete, Juan D.; Ordóñez, María del Carmen; Manrique-Arija, Sara; Vasilopoulos, Yiannis; Balsa, Alejandro; Pascual-Salcedo, Dora; Moreno-Ramos, Manuel J.; Alegre-Sancho, Juan José; Navarro-Sarabia, Federico; Moreira, Virginia; García-Portales, Rosa; Raya, Enrique; Magro-Checa, Rosa; Martín, Javier; Gómez-Reino, Juan J.; González, Antonio (PLoS, 2018-05-07)
      [Abstract] Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. ...

    • Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis 

      López-Lasanta, María; Juliá, Antonio; Maymó, Joan; Fernández-Gutiérrez, Benjamín; Ureña-Garnica, Inmaculada; Blanco García, Francisco J; Cañete, Juan D.; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Tornero, Jesús; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Ávila, Gabriela; Rodríguez-Rodríguez, Luis; Alonso, Arnald; Tortosa, Raül; González-Álvaro, Isidoro; Marsal, Sara (BMC, 2015-09-04)
      [Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...

    • Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (MDPI, 2020-08-25)
      [Abstract] Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs ...

    • What did we learn from 'omics' studies in osteoarthritis 

      Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Blanco García, Francisco J (Wolters Kluwer, 2018-01-01)
      [Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for ...

    • Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12 

      Pérez-García, Selene; Carrión, Mar; Villanueva-Romero, Raúl; Hermida Gómez, Tamara; Fernández-Moreno, Mercedes; Mellado, Mario; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (Wiley, 2019-03-22)
      [Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...