Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 89-108 de 184

    • Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus 

      Alonso-Pérez, Elisa; Suárez-Gestal, Marian; Calaza, Manuel; Blanco García, Francisco J; Suárez, Ana; Santos, María José; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-06-19)
      [Abstract] INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in their Chondrogenic Potential and Imbalance in their Response to Oxidative Stress 

      Mateos, Jesús; Fuente, Alexandre de la; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Arufe, M.C.; Blanco García, Francisco J (Elsevier, 2013-07-26)
      [Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ...

    • Leukocyte telomere length in patients with radiographic knee osteoarthritis 

      Mosquera, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Wiley, 2019-11-29)
      [Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...

    • Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro 

      Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)
      [Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...

    • Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis 

      Juliá, Antonio; Gómez, Antonio; López-Lasanta, María; Blanco García, Francisco J; Erra, Alba; Fernández-Nebro, Antonio; Juan Mas, Antonio; Pérez-García, Carolina; García Vivar, María Luz; Sánchez-Fernández, Simón; Alperi-López, Mercedes; Sanmartí, Raimon; Ortiz, Ana María; Marras Fernández-Cid, Carlos; Díaz-Torné, César; Moreno, Estefanía; Li, Tianlu; Martínez-Mateu, Sergio H.; Absher, Devin M.; Myers, Richard M.; Tornero Molina, Jesús; Marsal, Sara (Elsevier, 2022-05-13)
      [Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify ...

    • Long‐term safety, efficacy, and quality of life in patients with juvenile idiopathic arthritis treated with intravenous abatacept for up to seven years 

      Lovell, Daniel J.; Ruperto, Nicolino; Mouy, Richard; Paz, Eliana; Rubio-Përez, Nadina; Silva, Clovis A.; Abud-Mendoza, Carlos; Burgos-Vargas, Rubén; Gerloni, Valeria; Melo-Gomes, José A.; Saad-Magalhaes, Claudia; Chávez-Corrales, J.; Huemer, Christian; Kivitz, Alan; Blanco García, Francisco J; Foeldvari, Ivan; Hofer, Michael; Huppertz, Hans-Iko; Deslandre, Chantal Job; Minden, Kirsten; Punaro, Marilynn; Block, Alan J.; Giannini, Edward H.; Martini, Alberto (Wiley, 2015-06-19)
      [Abstract] Objective. The efficacy and safety of abatacept in patients with juvenile idiopathic arthritis (JIA) who experienced an inadequate response to disease‐modifying antirheumatic drugs were previously established ...

    • Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort 

      Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)
      [Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ...

    • Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 

      Cortes, Adrian; Pulit, Sara L.; Leo, Paul J.; Pointon, Jenny J.; Robinson, Philip C.; Weisman, Michael H.; Ward, Michael; Gensler, Lianne S.; Zhou, Xiaodong; Garchon, Henri-Jean; Chiocchia, Gilles; Nossent, Johannes; Lie, Benedicte A.; Øystein, Førre; Tuomilehto, Jaako; Laiho, Kari; Bradbury, Linda A.; Elewaut, Dirk; Burgos-Vargas, Rubén; Stebbings, Simon; Appleton, Louise; Farrah, Claire; Lau, Jonathan; Haroon, Nigil; Mulero, Juan; Blanco García, Francisco J; González-Gay, Miguel Á.; López-Larrea, Carlos; Bowness, Paul; Gaffney, Karl; Gaston, Hill; Gladman, Dafna D.; Rahman, Proton; Maksymowych, Walter P.; Crusius, Bart A.; van der Horst-Buinsma, Irene E.; Valle-Oñate, Raphael; Romero-Sánchez, Consuelo; Hansen, Inger Myrnes; Pimentel-Santos, Fernando M.; Inman, Robert D.; Martín, Javier; Breban, Maxime; Wordsworth, Bryan Paul; Reveille, John D.; Evans, David M.; Bakker, Paul I.W. de; Brown, Matthew A. (Nature, 2015-05-21)
      [Abstract] Article Open Access Published: 21 May 2015 Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 Adrian Cortes, Sara L. Pulit, Paul J. ...

    • Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect 

      Styrkarsdottir, Unnur; Stefansdottir, Lilja; Thorleifsson, Gudmar; Stefansson, Olafur A.; Saevarsdottir, Saedis; Lund, Sigrun H.; Rafnar, Thorunn; Hoshijima, Kazuyuki; Novak, Kendra; Oreiro, Natividad; Rego-Pérez, Ignacio; Hansen, Channing; Kazmers, Nikolas; Kiemeney, Lambertus A.; Blanco García, Francisco J; Barker, Tyler; Kloppenburg, Margreet; Jurynec, Michel J.; Gudbjartsson, Daniel F.; Jonsson, Helgi; Thorsteinsdottir, Unnur; Stefansson, Kari (BMJ, 2023-03-17)
      [Abstract] Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been ...

    • Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations 

      Márquez, Ana; Kerick, Martin; Zhernakova, Alexandra; Gutiérrez-Achury, Javier; Chen, Wei-Min; Onegut-Gumuscu, Suna; González-Álvaro, Isidoro; Rodríguez-Rodríguez, Luis; Ríos-Fernández, Raquel; González-Gay, Miguel Á.; Mayes, Maureen D.; Raychaudhuri, Soumya; Rich, Stephen S.; Wijmenga, Cisca; Martín, Javier (BMC, 2018-12-20)
      [Abstract] Background. In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The ...

    • Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis 

      Blanco García, Francisco J; Rego-Pérez, Ignacio (Elsevier, 2018-05-29)

    • Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells 

      López-Armada, María José; Caramés, Beatriz; Martín, M.A.; Cillero-Pastor, B.; Lires-Dean, M.; Fuentes Boquete, Isaac Manuel; Arenas, J.; Blanco García, Francisco J (Elsevier, 2006-05-05)
      [Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...

    • Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis 

      Blanco García, Francisco J; Fernández-Moreno, Mercedes (Elsevier, 2020-05-14)
      [Abstract] Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, ...

    • Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (BioMed Central, 2011-11-22)
      [Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...

    • Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI) 

      Soto-Hermida, Ángel; Fernández-Moreno, Mercedes; Oreiro, Natividad; Fernández-López, Carlos; Pértega-Díaz, Sonia; Cortés-Pereira, Estefanía; Rego-Pérez, Ignacio; Blanco García, Francisco J (PLoS, 2014-11-12)
      [Abstract] OBJECTIVE: To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ...

    • Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes 

      Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)
      [Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...

    • Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Hermida Gómez, Tamara; Lund, Jenny; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J; Fernández-Moreno, Mercedes (Elsevier, 2022-05)
      [Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction ...

    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...

    • Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis 

      Rego-Pérez, Ignacio; Blanco García, Francisco J; Roemer, Frank W.; Guermazi, Ali; Ran, Di; Ashbeck, Erin L.; Fernández Moreno, Mercedes; Oreiro, Natividad; Hannon, Michael J.; Hunter, David J.; Kwoh, Kent (Elsevier, 2018-07-20)
      [Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ...