Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 73-92 de 184

    • Identification of a Distinct Lipidomic Profile in the Osteoarthritic Synovial Membrane by Mass Spectrometry Imaging 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Ruiz-Romero, Cristina; Paine, Martin R.L.; Cañete, Juan D.; Heeren, Ron M.A.; Blanco García, Francisco J (Elsevier, 2021-05)
      [Abstract] Objective: Synovial inflammation is one of the most characteristic events in different types of arthritis, including Osteoarthritis (OA). Emerging evidence also suggests the involvement of lipids in the regulation ...

    • IL6/sIL6R Regulates TNFα-Inflammatory Response in Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms 

      Valin, Álvaro; Del Rey, Manuel J.; Municio, Cristina; Usategui, Alicia; Romero, Marina; Fernández-Felipe, Jesús; Cañete, Juan D.; Blanco García, Francisco J; Ruano, Yolanda; Criado, Gabriel; Pablos, José L. (BioMed Central, 2020-10-30)
      [Abstract] Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts ...

    • Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)
      [Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...

    • Impact of prevalence ratios of chondroitin sulfate (CS)- 4 and -6 isomers derived from marine sources in cell proliferation and chondrogenic differentiation processes 

      López-Senra, Estefanía; Casal-Beiroa, Paula; López-Álvarez, Miriam; Serra, Julia; González, Pío; Valcárcel, Jesús; Vázquez, José Antonio; Burguera, Elena F.; Blanco García, Francisco J; Magalhaes, J. (MDPI, 2020-01-31)
      [Abstract] Osteoarthritis is the most prevalent rheumatic disease. During disease progression, differences have been described in the prevalence of chondroitin sulfate (CS) isomers. Marine derived-CS present a higher ...

    • Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Lund, Jenny; Hermida Gómez, Tamara; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández-Moreno, Mercedes (MDPI, 2020-03-27)
      [Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ...

    • In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis 

      Cheleschi, Sara; Calamia, Valentina; Fernández-Moreno, Mercedes; Biava, Mariangela; Giordani, Antonio; Fioravanti, Antonella; Anzini, Maurizio; Blanco García, Francisco J (Elsevier, 2018-08-25)
      [Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...

    • Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis 

      Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Fernández-López, Carlos; Oreiro, Natividad; de-Toro, Javier; Blanco García, Francico J (BioMed Central, 2023-03-30)
      [Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...

    • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)
      [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...

    • Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
      [Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...

    • Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy 

      Juliá, Antonio; López-Lasanta, María; Blanco García, Francisco J; Gómez, Antonio; Haro, Isabel; juan Más, Antonio; Erra, Alba; García-Vivar, María L.; Monfort, Jordi; Sánchez-Fernández, Simón; González, Isidoro; Alperi-López, Mercedes; Castellanos-Moreira, Raúl; Fernández-Nebro, Antonio; Díaz-Torné, César; Lastra, Raquel M.; Lladós, Jordi; Palau, Núria; Sanmartí, Raimon; Marsal, Sara (Springer, 2021-04-21)
      [Abstract] Background. Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients ...

    • Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Intraneural IFG-1 in cryopreserved nerve isografts increase neural regeneration and functional recovery in the rat sciatic nerve 

      González Porto, Sara Alicia; Doménech, Nieves; Blanco García, Francisco J; Centeno, Alberto; Rivadulla, Casto; Álvarez Jorge, Álvaro; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Oxford, 2018-07-27)
      [Abstract] Background: Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation. Objective: To evaulate the effect of ...

    • Is It Time for Epigenetics in Osteoarthritis? 

      Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2014-05-16)
      [Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...

    • Is osteoarthritis a mitochondrial disease?: what is the evidence 

      Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Blanco García, Francico J (Wolters Kluwer, 2022-01)
      [Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...

    • Isolation and characterization of mesenchymal stem cells from human amniotic membrane 

      Díaz-Prado, Silvia; Muíños-López, Emma; Hermida Gómez, Tamara; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-01-04)
      [Abstract] Introduction: The human amniotic membrane is a highly abundant and readily available tissue that may be useful for regenerative medicine and cell therapy. Aim: To compare two previously published protocols for ...

    • iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis 

      Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)
      [Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ...

    • Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus 

      Alonso-Pérez, Elisa; Suárez-Gestal, Marian; Calaza, Manuel; Blanco García, Francisco J; Suárez, Ana; Santos, María José; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-06-19)
      [Abstract] INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in their Chondrogenic Potential and Imbalance in their Response to Oxidative Stress 

      Mateos, Jesús; Fuente, Alexandre de la; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Arufe, M.C.; Blanco García, Francisco J (Elsevier, 2013-07-26)
      [Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ...

    • Leukocyte telomere length in patients with radiographic knee osteoarthritis 

      Mosquera, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Wiley, 2019-11-29)
      [Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...