Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 65-84 de 184

    • Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions 

      Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; García-Herrero, Carmen M.; Sánchez-Aragó, María; Cuezva, José M.; Galindo, María; Bravo, Beatriz; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (Nature, 2017-06-16)
      [Abstract] Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms ...

    • Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics 

      Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Fernández-López, J. Carlos; Oreiro, Natividad; De-Toro, Javier; Blanco García, Francisco J (MDPI, 2024-04-08)
      [Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ...

    • Human amniotic membrane as an alternative source of stem cells for regenerative medicine 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Cicione, Claudia; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2011-02-19)
      [Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...

    • Human amniotic mesenchymal stromal cells as favorable source for cartilage repair 

      Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Mary Ann Liebert, 2017-01-10)
      [Abstract] Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...

    • Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)
      [Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ...

    • Hydrogen sulfide and inflammatory joint diseases 

      Burguera, Elena F.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Bentham, 2017)
      [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...

    • Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint 

      Burguera, Elena F.; Vela Anero, Ángela; Gato Calvo, Lucía; Vaamonde-García, Carlos; Meijide-Faílde, Rosa; Blanco García, Francisco J (Springer, 2019-11-16)
      [Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ...

    • Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress 

      Medina-Luna, Daniel; Santamaría-Olmedo, Mónica Guadalupe; Zamudio-Cuevas, Yessica; Martínez-Flores, Karina; Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Clavijo-Cornejo, Denise; Hernández-Díaz, Cristina; Olivos-Meza, Anell; Gómez-Quiroz, Luis Enrique; Gutiérrez-Ruiz, María Concepción; Pineda, Carlos; Blanco García, Francisco J; Reginato, Anthony M.; López-Reyes, Alberto (BMC, 2017-06-12)
      [Abstract] Background, Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this ...

    • Identification of a Distinct Lipidomic Profile in the Osteoarthritic Synovial Membrane by Mass Spectrometry Imaging 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Ruiz-Romero, Cristina; Paine, Martin R.L.; Cañete, Juan D.; Heeren, Ron M.A.; Blanco García, Francisco J (Elsevier, 2021-05)
      [Abstract] Objective: Synovial inflammation is one of the most characteristic events in different types of arthritis, including Osteoarthritis (OA). Emerging evidence also suggests the involvement of lipids in the regulation ...

    • IL6/sIL6R Regulates TNFα-Inflammatory Response in Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms 

      Valin, Álvaro; Del Rey, Manuel J.; Municio, Cristina; Usategui, Alicia; Romero, Marina; Fernández-Felipe, Jesús; Cañete, Juan D.; Blanco García, Francisco J; Ruano, Yolanda; Criado, Gabriel; Pablos, José L. (BioMed Central, 2020-10-30)
      [Abstract] Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts ...

    • Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)
      [Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...

    • Impact of prevalence ratios of chondroitin sulfate (CS)- 4 and -6 isomers derived from marine sources in cell proliferation and chondrogenic differentiation processes 

      López-Senra, Estefanía; Casal-Beiroa, Paula; López-Álvarez, Miriam; Serra, Julia; González, Pío; Valcárcel, Jesús; Vázquez, José Antonio; Burguera, Elena F.; Blanco García, Francisco J; Magalhaes, J. (MDPI, 2020-01-31)
      [Abstract] Osteoarthritis is the most prevalent rheumatic disease. During disease progression, differences have been described in the prevalence of chondroitin sulfate (CS) isomers. Marine derived-CS present a higher ...

    • Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Lund, Jenny; Hermida Gómez, Tamara; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández-Moreno, Mercedes (MDPI, 2020-03-27)
      [Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ...

    • In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis 

      Cheleschi, Sara; Calamia, Valentina; Fernández-Moreno, Mercedes; Biava, Mariangela; Giordani, Antonio; Fioravanti, Antonella; Anzini, Maurizio; Blanco García, Francisco J (Elsevier, 2018-08-25)
      [Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...

    • Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis 

      Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Fernández-López, Carlos; Oreiro, Natividad; de-Toro, Javier; Blanco García, Francico J (BioMed Central, 2023-03-30)
      [Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...

    • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)
      [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...

    • Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
      [Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...

    • Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy 

      Juliá, Antonio; López-Lasanta, María; Blanco García, Francisco J; Gómez, Antonio; Haro, Isabel; juan Más, Antonio; Erra, Alba; García-Vivar, María L.; Monfort, Jordi; Sánchez-Fernández, Simón; González, Isidoro; Alperi-López, Mercedes; Castellanos-Moreira, Raúl; Fernández-Nebro, Antonio; Díaz-Torné, César; Lastra, Raquel M.; Lladós, Jordi; Palau, Núria; Sanmartí, Raimon; Marsal, Sara (Springer, 2021-04-21)
      [Abstract] Background. Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Intraneural IFG-1 in cryopreserved nerve isografts increase neural regeneration and functional recovery in the rat sciatic nerve 

      González Porto, Sara Alicia; Doménech, Nieves; Blanco García, Francisco J; Centeno, Alberto; Rivadulla, Casto; Álvarez Jorge, Álvaro; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Oxford, 2018-07-27)
      [Abstract] Background: Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation. Objective: To evaulate the effect of ...