Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 46-65 de 184

    • Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE) 

      Nash, Peter; Ohson, Kamal; Walsh, Jessica; Delev, Nikolay; Nguyen, Dianne; Teng, Lichen; Gómez-Reino, Juan J.; Aelion, Jacob (BMJ, 2018-01-17)
      [Abstract] Objective Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA. Methods Patients were randomised (1:1) to apremilast ...

    • Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis 

      Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...

    • Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes 

      Burguera, Elena F.; Vela-Anero, Á.; Magalhaes, J.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Elsevier, 2014-07)
      [Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...

    • Effectiveness of tapentadol prolonged release (PR) compared with oxycodone/naloxone PR for the management of severe chronic low back pain with a neuropathic component: a randomized, controlled, open‐label, phase 3b/4sStudy 

      Baron, Ralf; Likar, Rudolf; Martín-Mola, Emilio; Blanco García, Francisco J; Kennes, Lieven; Müller, Matthias; Falke, Dietmar; Steigerwald, Ilona (Wiley, 2015-06-12)
      [Abstract] OBJECTIVE: To evaluate the effectiveness of tapentadol prolonged release (PR) vs. oxycodone/naloxone PR in non-opioid-pretreated patients with severe chronic low back pain with a neuropathic pain component. ...

    • Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential 

      Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)
      [Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...

    • Efficacy, Safety and Cost-Effectiveness of Methotrexate, Adalimumab or Their Combination in Non-infectious Non-anterior Uveitis: A Protocol for a Multicentre, Randomised, Parallel Three Arms, Active-Controlled, Phase III Open Label With Blinded Outcome Assessment Study 

      Rivas, Ana Belén; López-Picado, Amanda; Calamia, Valentina; Carreño, Ester; Cocho, Lidia; Cordero-Coma, Miguel; Fonollosa, Alex; Hernández, Félix M. Francisco; García-Aparicio, Ángel; García-González, Javier; Mondéjar, José Juan; Lojo-Oliveira, Leticia; Martínez-Costa, Llucí; Muñoz, Santiago; Peiteado, Diana; Pinto, José Antonio; Rodríguez-Lozano, Beatriz; Pato, Esperanza; Díaz-Valle, David; Molina, Elena; Tebar, Luis Alberto; Rodríguez-Rodríguez, Luis; CoTHEIA Study Group (BMJ Publishing Group, 2022-03-22)
      [Abstract] Introduction: Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), ...

    • Epigenetics as a therapeutic target in osteoarthritis 

      Núñez-Carro, Carmen; Blanco-Blanco, Margarita; Villagrán-Andrade, Karla Mariuxi; Blanco García, Francisco J; Andrés, María C. de (MDPI, 2023-01-21)
      [Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered ...

    • Etanercept withdrawal and retreatment in nonradiographic axial spondyloarthritis: results of RE-EMBARK, an open-label phase IV trial 

      Van den Bosch, Filip; Wei, James Cheng-Chung; Nash, Peter; Blanco García, Francisco J; Graham, Daniela; Zang, Chuanbo; Arthur, Edmund; Borlenghi, Cecilia; Tsekouras, Vassilis; Vlahos, Bonnie; Deodhar, Atul (Journal of Rheumatology Publishing, 2023-04)
      [Abstract] Objective: RE-EMBARK investigated etanercept (ETN) withdrawal and retreatment in patients with nonradiographic axial spondyloarthritis (nr-axSpA) achieving inactive disease. Methods: Patients received ETN and ...

    • Evaluación económica de la monoterapia con tocilizumab frente a adalimumab en artritis reumatoide 

      Navarro-Sarabia, Federico; Blanco García, Francisco J; Álvaro Gracia, José María; García Meijide, Juan A.; Poveda, José Luis; Rubio-Rodríguez, Darío; Rubio-Terrés, Carlos (Ministerio de Sanidad, Consumo y Bienestar Social, 2013)
      [Resumen] Fundamento: Tocilizumab (TCZ) fue superior a adalimumab (ADA) en monoterapia en la reducción de los signos y síntomas de la artritis reumatoide del adulto (AR) en pacientes intolerantes o con respuesta inadecuada ...

    • Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept 

      Ferreiro-Iglesias, Aida; Montes, Ariana; Pérez-Pampin, Eva; Cañete, Juan D.; Raya, Enrique; Magro-Checa, César; Vasilopoulos, Yiannis; Cáliz, Rafael; Ferrer, Miguel Ángel; Joven, Beatriz; Carreira, Patricia; Balsa, Alejandro; Pascual-Salcedo, Dora; Blanco García, Francisco J; Moreno-Ramos, Manuel J.; Manrique-Arija, Sara; Ordoñez, María del Carmen; Alegre-Sancho, Juan J.; Narváez, Javier; Navarro-Sarabia, Federico; Moreira, Viriginia; Valor, Lara; García-Portales, Rosa; Márquez, Ana; Gómez-Reino, Juan J.; Martín, Javier; González, Antonio (PLoS, 2019-02-28)
      [Abstract] Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) ...

    • Expert recommendations on the interleukin 6 blockade in patients with rheumatoid arthritis 

      Tornero Molina, Jesús; Balsa Criado, Alejandro; Blanco García, Francico J; Blanco Alonso, Ricardo; Bustabad, Sagrario; Calvo Alen, Jaime; Corominas, Héctor; Fernández Nebro, Antonio; Román Ivorra, José Andrés; Sanmartí, Raimon (Elsevier, 2020-07)
      [Abstract] Objective: To draft recommendations on interleukin 6 (IL-6) blockade in rheumatoid arthritis (RA), based on best evidence and experience. Methods: A group of 10 experts on IL-6 blockade in RA was selected. ...

    • Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy 

      Nogueira Recalde, Uxía; Lorenzo Gómez, Irene; Blanco García, Francisco J; Loza, María Isabel; Grassi, Diego; Shirinsky, Valery; Shirinsky, Ivan; Lotz, Martin; Robbins, Paul D.; Domínguez, Eduardo; Caramés, Beatriz (Elsevier, 2019-07-05)
      [Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was ...

    • GaitSmart Motion Analysis Compared to Commonly Used Function Outcome Measures in the IMI-APPROACH Knee Osteoarthritis Cohort 

      van Helvoort, Eefje M.; Hodgings, Diana; Mastbergen, Simon; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J. (PLoS ONE, 2022-03-23)
      [Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...

    • Generating Rho-0 cells using mesenchymal stem cell lines 

      Fernández-Moreno, Mercedes; Hermida Gómez, Tamara; Gallardo, M. Esther; Dalmao-Fernández, Andrea; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J (PLoS, 2016-10-20)
      [Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ...

    • Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)
      [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...

    • Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2020-03)
      [Abstract] Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...

    • Generation of mesenchymal cell lines derived from aged donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

    • Genetic biomarkers in osteoarthritis: a quick overview 

      Rego-Pérez, Ignacio; Durán Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Faculty Opinions, 2021-11-10)
      [Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ...

    • GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways 

      López-Isac, Elena; Acosta-Herrera, Marialbert; Kerick, Martin; Assassi, Shervin; Satpathy, Ansuman T.; Granja, Jeffrey; Mumbach, Maxwell R.; Beretta, Lorenzo; Simeón, Carmen P.; Carreira, Patricia; Ortego-Centeno, Norberto; Castellvi, Iván; Bossini-Castillo, Lara; Carmona, F. David; Orozco, Gisela; Hunzelmann, Nicolas; Distler, Jörg H.W.; Franke, Andre; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Vries-Bouwstra, Jeska de; Wijmenga, Cisca; Koeleman, Bobby P.C.; Nordin, Annika; Padyukov, Leonid; Hoffmann-Vold, Anna-Maria; Lie, Benedicte; Proudman, Susanna; Stevens, Wendy; Nikpour, Mandana; Vyse, Timothy; Herrick, Ariane L.; Worthington, Jane; Denton, Christopher P.; Allarone, Yannick; Brown, Matthew A.; Radstake, Timothy R.D.J.; Fonseca, Carmen; Chang, Howard Y.; Mayes, Maureen D.; Martín, Javier (Nature, 2019-10-31)
      [Abstract] Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous ...

    • Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions 

      Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; García-Herrero, Carmen M.; Sánchez-Aragó, María; Cuezva, José M.; Galindo, María; Bravo, Beatriz; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (Nature, 2017-06-16)
      [Abstract] Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms ...