Listar INIBIC- REUMA - Artigos por título

Mostrando ítems 158-177 de 184

    • Sexual Dysfunction in Ostomized Patients: A Systematized Review 

      García Rodríguez, María Teresa; Barreiro Trillo, Adriana; Seijo Bestilleiro, Rocío; González-Martín, Cristina (MDPI, 2021-04-29)
      [Abstract] The impact of an ostomy has a negative influence on sexuality. Healthcare professionals focus the care on surgery, and consider the sexual life is little relevant to the patient recovery. The aim of this ...

    • Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers 

      Bonakdari, Hossein; Petellier, Jean-Pierre; Blanco García, Francisco J; Rego-Pérez, Ignacio; Durán-Sotuela, Alejandro; Aitken, Dawn; Jones, Graeme; Cicuttini, Flavia; Jamshidi, Afshin; Abram, François; Martel-Pelletier, Johanne (BioMed Central, 2022-09-12)
      [Abstract] Background. Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify ...

    • Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes 

      López-Reyes, Alberto; Medina-Luna, Daniel; Santamaría-Olmedo, Mónica; Martínez-Flores, Karina; Zamudio-Cuevas, Yessica; Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Olivos-Meza, Anell; Camacho-Rea, Carmen; Fernández-Moreno, Mercedes; Blanco García, Francisco J; Pineda, Carlos (Springer, 2021-03-16)
      [Abstract] We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms ...

    • Specific premature epigenetic aging of cartilage in osteoarthritis 

      Vidal-Bravo, Laura; López-Golán, Yolanda; Mera-Varela, Antonio; Rego-Pérez, Ignacio; Horvath, Steve; Zhang, Yuhua; Real, Álvaro del; Zhai, Guangju; Blanco García, Francisco J; Riancho, José A.; Gómez-Reino, Juan J.; González, Antonio (Impact Journals, 2016-09-28)
      [Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...

    • Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort 

      Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C.A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Wirth, Wolfgang (BioMed Central, 2022-11-17)
      [Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ...

    • Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis 

      Vaamonde-García, Carlos; Flórez-Fernández, Noelia; Torres Pérez, María Dolores; Lamas Vázquez, María José; Blanco García, Francisco J; Domínguez, Herminia; Meijide-Faílde, Rosa (Elsevier, 2021-01-26)
      [Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ...

    • Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period 

      Berenbaum, Francis; Blanco García, Francisco J; Guermazi, Ali; Miki, Kenji; Yamabe, Takaharu; Viktrup, Lars; Junor, Rod; Carey, William; Brown, Mark T.; West, Christine R.; Verburg, Kenneth M. (BMJ, 2020-03-31)
      [Abstract] Objective. Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods. This double-blind, ...

    • Subcutaneous Tanezumab for Osteoarthritis: Is the Early Improvement in Pain and Function Meaningful and Sustained? 

      Berenbaum, Francis; Langford, R.; Perrot, S.; Miki, Kenji; Blanco García, Francisco J; Yamabe, Takaharu; Isogawa, N.; Junor, Rod; Carey, William; Viktrup, Lars; West, Christine R.; Brown, Mark T.; Verburg, Kenneth M. (Wiley, 2021-03-16)
      [Abstract] Background: To evaluate if early improvements in pain and function with subcuta-neous tanezumab are meaningful and sustained over 24 weeks. Methods: Patients with moderate- to- severe osteoarthritis (hip or ...

    • Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping 

      Rocha Loureda, Beatriz; Illiano, Anna; Calamia, Valentina; Pinto, Gabriella; Amoresano, Angela; Ruiz-Romero, Cristina; Blanco García, Francisco J (Elsevier, 2021-10-20)
      [Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...

    • Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort 

      Wirth, Wolfgang; Maschek, Susanne; Marijnissen, Anne C.A.; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Roemer, Frank W.; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Jansen, Mylène (Elsevier, 2022-11-03)
      [Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ...

    • The addition of albumin improves Schwann cells viability in nerve cryopreservation 

      González Porto, Sara Alicia; Doménech, Nieves; González Rodríguez, Alba; Avellaneda Oviedo, Edgar Mauricio; Blanco García, Francisco J; Arufe, M.C.; Álvarez Jorge, Ángel; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Springer, 2018-04-26)
      [Abstract] The purpose of the current study was to establish a valid protocol for nerve cryopreservation, and to evaluate if the addition of albumin supposed any advantage in the procedure. We compared a traditional ...

    • The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort 

      Loef, Marieke; van de Stadt, L.; Böhringer, S.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Larkin, Jonathan; Lafeber, Floris P.J.G.; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Giera, M.; Ioan-Facsinay, Andreea; Kloppenburg, Margreet (Elsevier, 2022-05-27)
      [Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data ...

    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...

    • The phenotype of axial spondyloarthritis: is it dependent on HLA–B27 status? 

      Coates, Laura C.; Baraliakos, Xenofon; Blanco García, Francisco J; Alonso Blanco-Morales, Elena; Braun, Jurgen; Chadran, Vinod; Fernández-Sueiro, José Luis; FitzGerald, Oliver; Gallagher, Phil; Gladman, Dafna D.; Gubar, Elena; Korotaeva, Tatiana; Loginova, Elena; Lubrano, Ennio; Mulero, Juan; Pinto-Tasende, José A.; Queiro, Rubén; Sanz Sanz, Jesús; Szentpetery, Agnes; Helliwell, Philip S. (Wiley, 2020-02-26)
      [Abstract] Objective: To describe the radiographic phenotype of axial spondyloarthritis (SpA) according to the presence of HLA-B27. Methods: An international collaboration compared the radiographic phenotype of axial ...

    • The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics 

      González-Pujana, Ainhoa; Rementería, Aitor; Blanco García, Francisco J; Igartua, Manoli; Pedraz, José Luis; Santos-Vizcaíno, Edorta; Hernández, Rosa María (Taylor & Francis, 2017-10-27)
      [Abstract] Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy ...

    • Tips and Tricks for Successfully Culturing and Adapting Human Induced Pluripotent Stem Cells [Protocol] 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; López-Baltar, Isidoro; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Cell Press, 2021-12)
      [Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ...

    • Translation of clinical problems in osteoarthritis into pathophysiological research goals 

      van der Kraan, Peter M.; Berenbaum, Francis; Blanco García, Francisco J; De Bari, Cosimo; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsilidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik (BMJ, 2016-05-26)
      [Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ...

    • Tratamiento de lesiones del cartílago articular con terapia celular 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2008-11-13)
      [Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente. El carácter asintomático de estas lesiones propicia la progresiva degeneración articular y ...

    • Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets 

      Espona-Noguera, A.; Etxebarría-Elezgarai, J.; Sáenz del Burgo, L.; Cañibano-Hernández, A.; Gurruchaga, H.; Blanco García, Francisco J; Orive, G.; Hernández, Rosa M.; Benito-López, F.; Ciriza, J.; Basabe-Desmonts, L.; Pedraz, J.L. (Elsevier, 2019-02-10)
      [Abstract] Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty microcapsules, resulting in high therapeutic graft volumes that can enhance the ...

    • Umbilical Cord as a Mesenchymal Stem Cell Source for Treating Joint Pathologies 

      Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Baishideng, 2011-06-18)
      [Abstract] Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life. Regrettably, the regeneration of articular cartilage is a continuing challenge for biomedical ...