Listar Reumatoloxía por fecha de publicación

Mostrando ítems 21-40 de 191

    • Evaluación económica de la monoterapia con tocilizumab frente a adalimumab en artritis reumatoide 

      Navarro-Sarabia, Federico; Blanco García, Francisco J; Álvaro Gracia, José María; García Meijide, Juan A.; Poveda, José Luis; Rubio-Rodríguez, Darío; Rubio-Terrés, Carlos (Ministerio de Sanidad, Consumo y Bienestar Social, 2013)
      [Resumen] Fundamento: Tocilizumab (TCZ) fue superior a adalimumab (ADA) en monoterapia en la reducción de los signos y síntomas de la artritis reumatoide del adulto (AR) en pacientes intolerantes o con respuesta inadecuada ...

    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...

    • Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential 

      Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)
      [Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...

    • Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in their Chondrogenic Potential and Imbalance in their Response to Oxidative Stress 

      Mateos, Jesús; Fuente, Alexandre de la; Lesende-Rodríguez, Iván; Fernández-Pernas, Pablo; Arufe, M.C.; Blanco García, Francisco J (Elsevier, 2013-07-26)
      [Abstract] In the present study, we examined the effect of the over-expression of LMNA, or its mutant form progerin (PG), on the mesoderm differentiation potential of mesenchymal stem cells (MSCs) from human umbilical cord ...

    • Mitochondrial Respiratory Chain Dysfunction Modulates Metalloproteases -1, -3 and -13 in Human Normal Chondrocytes in Culture 

      Cillero-Pastor, B.; Rego-Pérez, Ignacio; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2013-08-09)
      [Abstract] Background. Mitochondrion has an important role in the osteoarthritis (OA) pathology. We have previously demonstrated that the alteration of the mitochondrial respiratory chain (MRC) contributes to the inflammatory ...

    • A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...

    • Nitric Oxide Compounds Have Different Effects Profiles on Human Articular Chondrocyte Metabolism 

      Andrés, María C. de; Maneiro, Emilia; Martín, Miguel A.; Arenas, Joaquín; Blanco García, Francisco J (BioMed Central, 2013-09-11)
      [Abstract] Introduction. The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase ...

    • Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies 

      Rodríguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdés, Ana M.; Arden, Nigel; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tonu; Garcés Aletá, Carlos M.; Gómez-Reino Carnota, Juan J.; Helgadottir, Hafids; Hofman, Albert; Jonsdottir, Ingilef; Kerkhof, Henneke J.M.; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E.; Ollier, William E.R.; Oreiro, Natividad; Panoutsopoulo, Kalliope; Ralston, Stuart H.; Ramos, Yolande F. M.; Riancho, José A.; Rivadeneira, Fernando; Slagboom, Eline; Styrkarsdottir, Unnur; Thorsteindottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, André G.; Wallis, Gillian A.; Wilkinson, J. Mark; Zhai, Yanyan; Felson, David T.; Ioannidis, John P.A.; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B.; Zeggini, Eleftheria; Spector, Timothy D.; González, Antonio (Wiley, 2013-12-10)
      [Abstract] Objective: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods: A total of 199 ...

    • Proteomic Applications in the Study of Human Mesenchymal Stem Cells 

      Mateos, Jesús; Arufe, M.C.; Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Blanco García, Francisco J (Multidisciplinary Digital Publishing Institute, 2014-02-07)
      Mesenchymal stem cells (MSCs) are undifferentiated cells with an unlimited capacity for self-renewal and able to differentiate towards specific lineages under appropriate conditions. MSCs are, a priori, a good target for ...

    • Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials 

      Sanjurjo-Rodríguez, Clara; Martínez Sánchez, A.H.; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Buján, J.; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (Elsevier, 2014-03-20)

    • Is It Time for Epigenetics in Osteoarthritis? 

      Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2014-05-16)
      [Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus 

      Alonso-Pérez, Elisa; Suárez-Gestal, Marian; Calaza, Manuel; Blanco García, Francisco J; Suárez, Ana; Santos, María José; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-06-19)
      [Abstract] INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...

    • Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes 

      Burguera, Elena F.; Vela-Anero, Á.; Magalhaes, J.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Elsevier, 2014-07)
      [Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...

    • Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily 

      Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)
      [Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI) 

      Soto-Hermida, Ángel; Fernández-Moreno, Mercedes; Oreiro, Natividad; Fernández-López, Carlos; Pértega-Díaz, Sonia; Cortés-Pereira, Estefanía; Rego-Pérez, Ignacio; Blanco García, Francisco J (PLoS, 2014-11-12)
      [Abstract] OBJECTIVE: To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ...

    • Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib 

      Hochberg, Marc C.; Martel-Pelletier, Johanne; Monfort, Jordi; Möller, Ingrid; Castillo, Juan Ramón; Arden, Nigel; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Domènech, Gema; Henrotin, Yves; Pap, Thomas; Richette, Pascal; Sawitze, Allen; Souich, Patrick du; Pelletier, Jean-Pierre (BMJ, 2015-01-14)
      [Abstract] Objectives. To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. Methods. Double-blind ...

    • Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study 

      Montes, Adriana; Pérez-Pampin, Eva; Navarro-Sarabia, Federico; Moreira, Virginia; Rodríguez de la Serna, Arturo; Magallanes, Berta; Vasilopoulos, Yiannis; Sarafidou, Theologia; Fernández.Nebro, Antonio; Ordóñez, María del Carmen; Narváez, Javier; Cañete, Juan D.; Márquez, Ana; Pascual-Salcedo, Dora; Joven, Beatriz; Carreira, Patricia; Moreno-Ramos, Manuel J.; Cáliz, Rafael; Ferrer, Miguel Ángel; García-Portales, Rosa; Blanco García, Francisco J; Magro, César; Raya, Enrique; Valor, Lara; Alegre-Sancho, Juan J.; Balsa, Alejandro; Martín, Javier; Plant, Darren; Isaacs, John; Morgan, Ann W.; Barton, Anne; Wilson, Anthony G. (BioMed Central, 2015-03-18)
      [Abstract] INTRODUCTION: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of ...

    • Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 

      Cortes, Adrian; Pulit, Sara L.; Leo, Paul J.; Pointon, Jenny J.; Robinson, Philip C.; Weisman, Michael H.; Ward, Michael; Gensler, Lianne S.; Zhou, Xiaodong; Garchon, Henri-Jean; Chiocchia, Gilles; Nossent, Johannes; Lie, Benedicte A.; Øystein, Førre; Tuomilehto, Jaako; Laiho, Kari; Bradbury, Linda A.; Elewaut, Dirk; Burgos-Vargas, Rubén; Stebbings, Simon; Appleton, Louise; Farrah, Claire; Lau, Jonathan; Haroon, Nigil; Mulero, Juan; Blanco García, Francisco J; González-Gay, Miguel Á.; López-Larrea, Carlos; Bowness, Paul; Gaffney, Karl; Gaston, Hill; Gladman, Dafna D.; Rahman, Proton; Maksymowych, Walter P.; Crusius, Bart A.; van der Horst-Buinsma, Irene E.; Valle-Oñate, Raphael; Romero-Sánchez, Consuelo; Hansen, Inger Myrnes; Pimentel-Santos, Fernando M.; Inman, Robert D.; Martín, Javier; Breban, Maxime; Wordsworth, Bryan Paul; Reveille, John D.; Evans, David M.; Bakker, Paul I.W. de; Brown, Matthew A. (Nature, 2015-05-21)
      [Abstract] Article Open Access Published: 21 May 2015 Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 Adrian Cortes, Sara L. Pulit, Paul J. ...