Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing
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Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensingAuthor(s)
Date
2012-04-28Citation
Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing. S. Abada, A. Lecointre, M. Elhabiri, D. Esteban-Gómez, C. Platas-Iglesias, G. Tallec, M. Mazzanti and L. J. Charbonnière, Chem. Commun., 2012, 48, 4085–4087.
Abstract
[Abstract] A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (logKEuL = 25.7), a high relaxivity (8.5 mM−1 s−1 at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg2+, opening interesting perspectives for the design of cation responsive contrast agents.
Keywords
MRI contrast agents
DFT calculations
Gadolinium complexes
Relaxivity
Magnesium sensing
DFT calculations
Gadolinium complexes
Relaxivity
Magnesium sensing
Editor version
ISSN
1359-7345
1364-548X
1364-548X