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Induced pluripotent stem cells for cartilage repair: current status and future perspectives
dc.contributor.author | Castro Viñuelas, Rocío | |
dc.contributor.author | Sanjurjo-Rodríguez, Clara | |
dc.contributor.author | Piñeiro-Ramil, María | |
dc.contributor.author | Hermida Gómez, Tamara | |
dc.contributor.author | Fuentes Boquete, Isaac Manuel | |
dc.contributor.author | De-Toro, Javier | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Díaz-Prado, Silvia | |
dc.date.accessioned | 2018-10-29T08:24:13Z | |
dc.date.available | 2018-10-29T08:24:13Z | |
dc.date.issued | 2018-09-11 | |
dc.identifier.citation | Castro-Viñuelas R, Sanjurjo-Rodríguez C, Piñeiro-Ramil M, Hermida Gómez T, Fuentes-Boquete IM, de Toro Santos FJ, et al. Induced pluripotent stem cells for cartilage repair: current status and future perspectives. Eur Cell Mater. 2918;36:96-109 | es_ES |
dc.identifier.issn | 1473-2262 | |
dc.identifier.uri | http://hdl.handle.net/2183/21212 | |
dc.description.abstract | [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells (MSCs) are prone to form epiphyseal or hypertrophic cartilage and have an age-related limited proliferation. On the other hand, it is difficult to obtain functional chondrocytes from human embryonic stem cells (ESCs). Moreover, the ethical issues associated with human ESCs are an additional disadvantage of using such cells. Since their discovery in 2006, induced pluripotent stems cells (iPSCs) have opened many gateways to regenerative medicine research, especially in cartilage tissue engineering therapies. iPSCs have the capacity to overcome limitations associated with current cell sources since large numbers of autologous cells can be derived from small starting populations. Moreover, problems associated with epiphyseal or hypertrophic-cartilage formation can be overcome using iPSCs. iPSCs emerge as a promising cell source for treating cartilage defects and have the potential to be used in the clinical field. For this purpose, robust protocols to induce chondrogenesis, both in vitro an in vivo, are required. This review summarises the recent progress in iPSC technology and its applications for cartilage repair. | es_ES |
dc.description.sponsorship | CIBER-BBN; Rede Galega de Terapia Celular and Grupos con Potencial de Crecemento, Xunta de Galicia (R2016/036, R2014/050 and GPC2014/048); Fondo de Investigación Sanitaria; Instituto de Salud Carlos III (PI17/02197). Clara Sanjurjo-Rodríguez is beneficiary of a postdoctoral fellowship from the Xunta de Galicia; Rocío Castro-Viñuelas and María Piñeiro-Ramil are granted by a predoctoral fellowship from the Xunta de Galicia and the European Union (European Social Fund - ESF); Fundación Española de Reumatología (2014 grant); Universidade da Coruña; Fundación Profesor Novoa Santos. | es_ES |
dc.description.sponsorship | Xunta de Galicia; R2016/036 | es_ES |
dc.description.sponsorship | Xunta de Galicia; R2014/050 | es_ES |
dc.description.sponsorship | Xunta de Galicia; GPC2014/048 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F02197/ES/CELULAS MADRE PLURIPOTENTES INDUCIDAS (IPS) COMO MODELO DE ARTROSIS DE MANOS | |
dc.language.iso | eng | es_ES |
dc.publisher | AO Research Institute Davos | es_ES |
dc.relation.uri | http://dx.doi.org/10.22203/eCM.v036a08 | es_ES |
dc.rights | Creative Commons Attribution-ShareAlike 4.0 International Licence (CC-BY-SA 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Induced pluripotent stem cells (iPS) | es_ES |
dc.subject | Pluripotency | es_ES |
dc.subject | Cartilage | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.subject | Cell therapy | es_ES |
dc.subject | Tissue engineering | es_ES |
dc.subject | Regenerative medicine | es_ES |
dc.subject | Chodrogenesis | es_ES |
dc.title | Induced pluripotent stem cells for cartilage repair: current status and future perspectives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | European Cells and Materials | es_ES |
UDC.volume | 36 | es_ES |
UDC.startPage | 96 | es_ES |
UDC.endPage | 109 | es_ES |
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